SAB5702243

Anti-FGL1 Antibody, clone 5M3E6, Rabbit Monoclonal

• Synonym(e): FGL1,HFREP1,HP-041,LFIRE-1,LFIRE1
• UNSPSC-Code: 12352203
• NACRES: NA.46

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Materialien: colorless
• Klon: 5M3E6, monoclonal
• Form: liquid
• Mol-Gew.: 35 kDa
• Speziesreaktivität: human
• Konzentration: 1.0mg/mL
• Methode(n): western blot: 1:500 - 1:1000
• Farbe: colorless
• Isotyp: IgG
• UniProt-Hinterlegungsnummer: Q08830
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... FGL1(2267)

Beschreibung

Allgemeine Beschreibung

Fibrinogen-like protein 1 (FGL1), a liver-secreted protein, is a major LAG-3 functional ligand independent from MHC-II. The FGL1-LAG-3 pathway maybe an important immune evasion mechanism and could contribute to current cancer immunotherapy efforts for several reasons. FGL1 inhibits antigen-specific T cell activation, and ablation of FGL1 in mice promotes T cell immunity. Blockade of the FGL1-LAG-3 interaction by monoclonal antibodies stimulates tumor immunity and is therapeutic against established mouse tumors in a receptor-ligand inter-dependent manner. FGL1 is highly produced by human cancer cells, and elevated FGL1 in the plasma of cancer patients is associated with a poor prognosis and resistance to anti-PD-1/B7-H1 therapy

Immunogen

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Recombinant protein of human FGL-1 Full length.

Anwendung

WB

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1