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SAB5200099

Sigma-Aldrich

Anti-HSPB2 antibody produced in rabbit

1 mg/mL, affinity isolated antibody

Synonym(e):

Anti-Anti-HSPB2 (MKBP), Anti-DMPK-binding protein, Anti-HspB2, Anti-MGC133245, Anti-heat shock 27kDa protein 2

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous glycerol solution

Mol-Gew.

antigen predicted mol wt 27 kDa

Speziesreaktivität

rat, human, mouse

Konzentration

1 mg/mL

Methode(n)

western blot: suitable

NCBI-Hinterlegungsnummer

NP_001532.1

UniProt-Hinterlegungsnummer

Q16082

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... HSPB2(3316)

Verwandte Kategorien

Allgemeine Beschreibung

Heat shock protein family B, member 2 (HSPB2) is also called as myotonic dystrophy kinase binding protein (MKBP). It is expressed in the skeletal muscles and heart. Studies have also shown that HSPB2 is overexpressed in lung fibrosis. The gene encoding it is localized on human chromosome 11q22-q23. The gene ID of the protein is 3316.

Spezifität

Detects ~27 kDa.

Immunogen

Synthetic peptide

Biochem./physiol. Wirkung

Heat shock protein family B, member 2 (HSPB2) binds to ubiquitin and hydrogen peroxide-inducible clone 5, an adaptor protein. This association is important for the ubiquitination and degradation of NADPH oxidase 4 (Nox4). It is also crucial for the degradation of other proteins. HSPB2 interacts with myotonic dystrophy protein kinase (DMPK) and activates it.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

PBS, 50% glycerol, and 0.02% sodium azide

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Leena P Desai et al.
The Journal of biological chemistry, 289(26), 18270-18278 (2014-05-17)
Hydrogen peroxide-inducible clone 5 (Hic-5) is a focal adhesion adaptor protein induced by the profibrotic cytokine TGF-β1. We have demonstrated previously that TGF-β1 induces myofibroblast differentiation and lung fibrosis by activation of the reactive oxygen species-generating enzyme NADPH oxidase 4
Sankaralingam Prabhu et al.
PloS one, 7(1), e29810-e29810 (2012-01-25)
The small heat shock protein, human HspB2, also known as Myotonic Dystrophy Kinase Binding Protein (MKBP), specifically associates with and activates Myotonic Dystrophy Protein Kinase (DMPK), a serine/threonine protein kinase that plays an important role in maintaining muscle structure and
Xiaofei Chang et al.
International journal of oncology, 38(4), 1129-1135 (2011-01-25)
Hypermethylation of gene promoters and the corresponding loss of gene expression are recognized as a hallmark of human cancer, and DNA methylation has emerged as a promising biomarker for the detection of human esophageal squamous cell carcinoma (ESCC). To identify

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