SAB4700284
Monoclonal Anti-CD15 antibody produced in mouse
clone MEM-158, purified immunoglobulin, buffered aqueous solution
Synonym(e):
Anti-FUT4, Anti-Lewis x Blood Group antigen
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About This Item
UNSPSC-Code:
12352203
NACRES:
NA.41
Empfohlene Produkte
Biologische Quelle
mouse
Konjugat
unconjugated
Antikörperform
purified immunoglobulin
Antikörper-Produkttyp
primary antibodies
Klon
MEM-158, monoclonal
Form
buffered aqueous solution
Speziesreaktivität
human
Konzentration
1 mg/mL
Methode(n)
flow cytometry: suitable
Isotyp
IgM
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Lagertemp.
2-8°C
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... FUT4(2526)
Verwandte Kategorien
Allgemeine Beschreibung
Cluster of differentiation 15 (CD15), also known as fucosyltransferase 4 (FUT4)/ Lewis x blood group antigen, is encoded by the gene mapped to long arm of human chromosome 11q21. It is ubiquitously expressed in various tissues such as gastrointestinal tract, brain and leukocytes.
The antibody MEM-158 reacts with CD15, a cell membrane molecule 3-fucosyl-N-acetyllactosamine (3-FAL) strongly expressed on granulocytes, monocytes, macrophages, mast cells; it is also present on Langerhans cells and some myeloid precursors cells.
Immunogen
Human granulocytes
Anwendung
The reagent is designed for Flow Cytometry analysis using 10 μL reagent / 100 μL of sample.
Biochem./physiol. Wirkung
Cluster of differentiation 15 (CD15)/fucosyltransferase 4 catalyzes the synthesis of Lex on the surface of the proliferating cells, in organ buds progressing in mesenchyma, during human embryogenesis. Overexpression of the gene has been associated with development of various type of cancers such as colon cancer, pancreatic cancer, gastric cancer and lung adenocarcinoma. siRNAs of FUT1/4 can be used as a potent therapeutic agent in human LeY-expressing cancers.
Leistungsmerkmale und Vorteile
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physikalische Form
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
10 - Combustible liquids
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
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Sakiko Masuda et al.
The American journal of pathology, 189(4), 839-846 (2019-01-25)
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by the production of ANCAs and systemic necrotizing vasculitis in small vessels. Disordered regulation of neutrophil extracellular traps (NETs) is critically involved in the pathogenesis of AAV. NETs are web-like DNA decorated
Wei Jin et al.
Annals of surgical oncology, 26(2), 635-643 (2018-10-31)
Tumor-infiltrating neutrophils (TINs) indicate poor prognosis for patients with pancreatic ductal adenocarcinoma (PDAC). Activated neutrophils can generate neutrophil extracellular traps (NETs). Little is known about the presence and prognostic significance of tumor-infiltrating NETs in PDAC. This study enrolled 317 patients
The gene encoding myeloid alpha-3-fucosyl-transferase (FUT4) is located between D1 1S388 and D11S919 on 11q21.
Reguigne I
Cytogenetics and Cell Genetics, 66, 104-106 (1994)
David Weisenburger-Lile et al.
Neurology(R) neuroimmunology & neuroinflammation, 6(4), e571-e571 (2019-07-30)
To better understand the functional state of circulating neutrophils in patients with ischemic stroke (IS) for planning future clinical trials. We analyzed by flow cytometry activation state of circulating neutrophils and the distribution of neutrophil peripheral subsets in 41 patients
Filippo Veglia et al.
Nature, 569(7754), 73-78 (2019-04-19)
Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are pathologically activated neutrophils that are crucial for the regulation of immune responses in cancer. These cells contribute to the failure of cancer therapies and are associated with poor clinical outcomes. Despite recent advances in
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