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Merck

SAB4502725

Sigma-Aldrich

Anti-CHP2 antibody produced in rabbit

affinity isolated antibody

Synonym(e):

Calcineurin B homologous protein 2, Hepatocellular carcinoma-associated antigen 520

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 22 kDa

Speziesreaktivität

rat, mouse, human

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:40000
western blot: 1:500-1:1000

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... CHP2(63928)

Allgemeine Beschreibung

Anti-CHP2 antibody detects endogenous levels of total CHP2 protein.
The CHP2 (calcineurin like EF-hand protein 2) gene is mapped to human chromosome 16p12.2. It encodes a 23kDa protein containing myristoylation site at its N-terminal and four EF-hand Ca2+ binding motifs. The gene is predominantly expressed in small intestine and cancer cells.

Immunogen

The antiserum was produced against synthesized peptide derived from human CHP2.

Immunogen Range: 101-150

Biochem./physiol. Wirkung

The protein encoded by CHP2 (calcineurin like EF-hand protein 2) gene serves as an important cofactor of Na+/H+ exchanger isoform 1 and maintains high intracellular pH in cancer cells. CHP2 protects cells from dying due to serum deprivation. Overexpression of the gene is observed in ovarian cancer and it is involved in the growth, proliferation, invasion and metastasis of cancer cells.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Overexpression of CHP2 enhances tumor cell growth, invasion and metastasis in ovarian cancer.
Jin Q
In Vivo, 21(4), 593-598 (2007)
Crystallization and preliminary crystallographic analysis of the human calcineurin homologous protein CHP2 bound to the cytoplasmic region of the Na+/H+ exchanger NHE1.
Ben Ammar Y
Acta Crystallographica Section F, Structural Biology and Crystallization Communications, 61(Pt 10), 956-958 (2005)
Nuclear accumulation of calcineurin B homologous protein 2 (CHP2) results in enhanced proliferation of tumor cells.
Li QH
Genes Cells, 16(4), 416-426 (2011)
Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation.
Ammar YB
The Embo Journal, 25(11), 2315-2325 (2006)

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