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Merck

SAB4501901

Sigma-Aldrich

Anti-MMP-14 antibody produced in rabbit

affinity isolated antibody

Synonym(e):

MATRIX METALLOPROTEINASE 14, MEMBRANE-TYPE, MEMBRANE-TYPE MATRIX METALLOPROTEINASE 1, MT1-MMP, matrix metalloproteinase 14 (membrane-inserted)

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 65 kDa

Speziesreaktivität

mouse, rat, human

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... MMP14(4323)

Allgemeine Beschreibung

Anti-MMP-14 Antibody detects endogenous levels of total MMP-14 protein. Matrix metalloproteinase-14 (MMP-14) is a collagenase localized to the cell membrane. The gene encoding it is present on human chromosome 14.

Immunogen

The antiserum was produced against synthesized peptide derived from human MMP-14.

Immunogen Range: 471-520

Biochem./physiol. Wirkung

Matrix metalloproteinase-14 (MMP-14) aids in the migration of leukocytes and breaks down collagen. Migration of cells through the extracellular matrix is also mediated by it. MMP-14 has been shown to be associated with tuberculosis and glioma.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Membrane Type 1 Matrix Metalloproteinase Regulates Monocyte Migration and Collagen Destruction in Tuberculosis.
Sathyamoorthy T
Journal of Immunology (2015)
Marta Smeda et al.
Breast cancer research : BCR, 20(1), 86-86 (2018-08-05)
Mesenchymal transformation of pulmonary endothelial cells contributes to the formation of a metastatic microenvironment, but it is not known whether this precedes or follows early metastasis formation. In the present work, we characterize the development of nitric oxide (NO) deficiency
MT1-MMP silencing by an shRNA-armed glioma-targeted conditionally replicative adenovirus (CRAd) improves its anti-glioma efficacy in vitro and in vivo.
Ulasov I
Cancer Letters (2015)
Marta Smeda et al.
Oncotarget, 9(25), 17810-17824 (2018-05-01)
Platelet inhibition has been considered an effective strategy for combating cancer metastasis and compromising disease malignancy although recent clinical data provided evidence that long-term platelet inhibition might increase incidence of cancer deaths in initially cancer-free patients. In the present study
Matrix metalloproteinases in skin.
Kahari VM, Ssaarialho K
Experimental Dermatology (1997)

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