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Merck

SAB4501885

Sigma-Aldrich

Anti-MLK3 antibody produced in rabbit

affinity isolated antibody

Synonym(e):

M3K11, MAP3K11, MAPKKK11, kinase MLK3, mitogen activated protein kinase kinase kinase 11

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 92 kDa

Speziesreaktivität

human, rat, mouse

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:20000
immunohistochemistry: 1:50-1:100

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... MAP3K11(4296)

Allgemeine Beschreibung

Anti-MLK3 Antibody detects endogenous levels of total MLK3 protein.
Mitogen-activated protein kinase kinase kinase 11 (MAP3K11) or mixed lineage kinase 3 (MLK3) possesses an amino-terminal Src-homology-3 (SH3) domain followed by a kinase domain, a leucine-zipper region, a Cdc42/RAC interacting motif (CRIB) and a carboxy terminal proline/serine/threonine-rich domain. The gene encoding this serine/threonine protein kinase is localized on human chromosome 11q13.1.

Immunogen

The antiserum was produced against synthesized peptide derived from human MLK3.

Immunogen Range: 640-689

Biochem./physiol. Wirkung

Mitogen-activated protein kinase kinase kinase 11 (MAP3K11), also known as mixed lineage kinase 3 (MLK3), phosphorylates c-Jun N-terminal kinases. It acts as a modulator of the mitogen-activated protein kinase (MAPK) pathway. The protein is associated with various cancers.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Die Dokumentenbibliothek aufrufen

Hepatitis C virus NS5A inhibits mixed lineage kinase 3 to block apoptosis.
Amako Y, et al.
The Journal of Biological Chemistry, 288(34), 24753-24763 (2013)
Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation.
Velho S, et al.
BMC Cancer, 14(1), 182-182 (2014)
MLK3 is part of a feedback mechanism that regulates different cellular responses to reactive oxygen species.
Lee HS, et al.
Science Signaling, 7(328), ra52-ra52 (2014)
Wayne Bowden et al.
Molecular human reproduction, 15(9), 563-568 (2009-07-02)
Uterine leiomyomas (ULs) are benign monoclonal tumors originating from myometrial tissue in the uterus. Genetic pathways that lead to myometrial transformation into leiomyomas are largely unknown. Approximately 40% of ULs are karyotypically abnormal by G-banding; however, the remaining 60% of

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