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Merck

SAB4501821

Sigma-Aldrich

Anti-TAU antibody produced in rabbit

affinity isolated antibody

Synonym(e):

MAPT, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau

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About This Item

MDL-Nummer:
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen 78 kDa

Speziesreaktivität

mouse, rat, human

Konzentration

~1 mg/mL

Methode(n)

ELISA: 1:20000
western blot: 1:500-1:1000

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... MAPT(4137)

Allgemeine Beschreibung

Anti-TAU antibody detects endogenous levels of total TAU protein.
MAPT (microtubule associated protein tau) is located on human chromosome 17q21.3. It is expressed in neurons but is most prominent in axons.

Immunogen

The antiserum was produced against synthesized peptide derived from human Tau.

Immunogen Range: 501-550

Biochem./physiol. Wirkung

Removal of MAPT results in developmental delay and learning disability. It participates in the pathology of Alzheimer′s disease (AD). It helps in the assembly and maintenance of microtubule structure.

Leistungsmerkmale und Vorteile

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Youssra K Al-Hilaly et al.
Methods in molecular biology (Clifton, N.J.), 2551, 163-188 (2022-11-01)
Tau is a natively unfolded protein that contributes to the stability of microtubules. Under pathological conditions such as Alzheimer's disease (AD), tau protein misfolds and self-assembles to form paired helical filaments (PHFs) and straight filaments (SFs). Full-length tau protein assembles
Youssra K Al-Hilaly et al.
FEBS letters, 594(5), 944-950 (2019-11-14)
The constituent paired helical filaments (PHFs) in neurofibrillary tangles are insoluble intracellular deposits central to the development of Alzheimer's disease (AD) and other tauopathies. Full-length tau requires the addition of anionic cofactors such as heparin to enhance assembly. We have
Robert Prucek et al.
Scientific reports, 11(1), 6240-6240 (2021-03-20)
Targeted and effective therapy of diseases demands utilization of rapid methods of identification of the given markers. Surface enhanced Raman spectroscopy (SERS) in conjunction with streptavidin-biotin complex is a promising alternative to culture or PCR based methods used for such
Microdeletion encompassing MAPT at chromosome 17q21.3 is associated with developmental delay and learning disability
Shaw-Smith C
Nature Genetics, 38(9), 1032-1037 (2006)
Linkage disequilibrium and association of MAPT H1 in Parkinson disease
Skipper L, et al.
American Journal of Human Genetics, 75(4), 669-677 (2004)

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