SAB4200685

Anti-Glucagon antibody, Mouse monoclonal

clone K79bB10, purified from hybridoma cell culture

• Synonym(e): Monoclonal Anti-Glucagon antibody produced in mouse, GCG, GLP1, GLP2, GRPP
• UNSPSC-Code: 51111800
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 200
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: K79bB10, monoclonal
• Form: buffered aqueous solution
• Speziesreaktivität: cat, rabbit, mouse, guinea pig, rat, dog, porcine, zebrafish, human
• Verpackung: antibody small pack of 25 μL
• Konzentration: ~1 mg/mL
• Methode(n): immunohistochemistry: 5-10 μg/mL using heat−retrieved formalin-fixed, paraffin-embedded Rat pancreas sections and Biotin/ExtrAvidin^®-Peroxidase staining system.; radioimmunoassay: suitable
• Isotyp: IgG1
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: cat ... Gcg(101097825) ; dog ... Gcg(403571) ; guinea pig ... Gcg(100135526) ; human ... GCG(2641) ; mouse ... Gcg(14526) ; pig ... Gcg(397595) ; rabbit ... Gcg(100341777) ; rat ... Gcg(24952)

Beschreibung

Allgemeine Beschreibung

Glucagon is a hormone peptide produced in Langerhans islets α-cells in the pancreas. The active form of glucagon is derived from the cleavage of preproglucagon (GCG). Additional cleavage peptides are oxyntomodulin and glucagon-like peptide-1 (GLP1).

Immunogen

Polymerized porcine glucagon

Anwendung

Monoclonal Anti-Glucagon antibody produced in mouse has been used in immunofluorescence staining. The product may be used in several immunochemical techniques including immunohistochemistry and radioimmunoassay (RIA).

Biochem./physiol. Wirkung

The biological activities of pancreatic glucagon include glycogenolysis, lipolysis, gluconeogenesis and ketogenesis. Glucagon has an antagonistic effect in the maintenance of normoglycemia to those of insulin and is suppressed by GLP1. Thus up-regulation of glucagon is leading to increased blood glucose levels. Glucagon-specific antibodies would prove useful as a Langerhans islets α cell, glucagonomas and tumor markers applying immunohistochemical techniques, and as an analytical tool in quantification of the hormone.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Rechtliche Hinweise

ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable