SAB4200427

Anti-COG8 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Synonym(e): Anti-CDG2H, Anti-COG complex subunit 8, Anti-Component of oligomeric golgi complex 8, Anti-conserved oligomeric Golgi complex subunit 8, Anti-conserved oligomeric golgi complex component 8, Anti-dependent on RIC1, AntiDOR1
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~70 kDa
• Speziesreaktivität: human
• Konzentration: ~1.0 mg/mL
• Methode(n): immunoprecipitation (IP): 5-10 μg using lysates of human HEK-293T cells; indirect immunofluorescence: 0.5-1.0 μg/mL using using human HeLa cells; western blot: 1-2 μg/mL using whole extracts of human HEK-293 cells
• UniProt-Hinterlegungsnummer: Q96MW5
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... COG8(84342)

Beschreibung

Allgemeine Beschreibung

Conserved oligomeric Golgi complex 8 (COG8), also known as DOR1 or CDG2H, is a member of the conserved oligomeric Golgi (COG) complex. COG complex is composed of eight distinct subunits organized as heterotrimeric groups namely Cog2-Cog3-Cog4 and Cog5-Cog6-Cog7. They are interlinked by the dimeric group comprising Cog1 and Cog8.

Spezifität

Anti-COG8 (C-terminal) recognizes human COG8.

Immunogen

synthetic peptide corresponding to the C-terminal region of human COG8, conjugated to KLH

Anwendung

Anti-COG8 (C-terminal) antibody produced in rabbit may be used in:

• immunoblotting
• immunoprecipitation
• immunofluorescence

Biochem./physiol. Wirkung

COG complex, is an evolutionarily conserved multi-subunit protein complex that regulates membrane trafficking and maintenance of Golgi glycosylation machinery in eukaryotic cells. Mutations in the COG8 gene cause congenital disorder of glycosylation, type IIh, a disease that is characterized by under-glycosylated serum proteins, and whose symptoms include severe psychomotor retardation, failure to thrive, seizures, and dairy and wheat product intolerance.

Physikalische Form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide

Lagerung und Haltbarkeit

For continuous use, store at 2-8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable