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Merck

SAB4100327

Sigma-Aldrich

Monoclonal Anti-ADIPOQ antibody produced in mouse

clone ADIPOQ-A277, culture supernatant

Synonym(e):

Anti-ACDC, Anti-ACRP30, Anti-ADIPQTL1, Anti-ADPN, Anti-APM-1, Anti-APM1, Anti-Adiponectin, C1Q and collagen domain containing, Anti-GBP28

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Konjugat

unconjugated

Antikörperform

culture supernatant

Antikörper-Produkttyp

primary antibodies

Klon

ADIPOQ-A277, monoclonal

Form

aqueous solution

Mol-Gew.

antigen predicted mol wt 24.9 kDa

Speziesreaktivität

human

Methode(n)

western blot: suitable

Isotyp

IgG1

UniProt-Hinterlegungsnummer

Versandbedingung

dry ice

Lagertemp.

−20°C

Angaben zum Gen

human ... ADIPOQ(9370)

Allgemeine Beschreibung

Adiponectin (ADIPOQ) gene is mapped to human chromosome 3q27.3. The gene codes for a 244 amino acid protein with four distinct regions. ADIPOQ is secreted by the adipocytes and is a most abundant circulating hormone.

Immunogen

ADIPOQ purified recombinant protein

Biochem./physiol. Wirkung

Adiponectin (ADIPOQ) is an adipocyte specific secreted protein that circulates in the plasma. The protein has a C-terminal globular domain and an NH2-terminal collagen domain. It has anti-atherosclerotic and anti-inflammatory properties. ADIPOQ has a role in physiological processes such as energy homeostasis and obesity. It exhibits anti-diabetic action by interacting with adiponectin receptors, AdipoR1 and AdipoR2. Low levels of adiponectin are also linked with hypertension and dyslipidemia. Mutation in the gene encoding it is linked with risk for endometrial cancer.

Physikalische Form

Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1,727 healthy Caucasians
Heid IM, et al.
Diabetes, 55, 375-384 (2019)
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
Kadowaki T, et al.
The Journal of Clinical Investigation, 116, 1784-1792 (2019)
Association Between Single Nucleotide Polymorphism +276G T (rs1501299) in ADIPOQ and Endometrial Cancer
Bienkiewicz J, et al.
Pathology Oncology Research, 22, 135-138 (2019)
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta K, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology (2000)
In silico Evaluation of Nonsynonymous Single Nucleotide Polymorphisms in the ADIPOQ Gene Associated with Diabetes, Obesity, and Inflammation
Swamy AN, et al.
Avicenna Journal of Medical Biotechnology, 7(6), 121-121 (2015)

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