SAB4100064

Monoclonal Anti-IDH1 antibody produced in mouse

clone IDH1-A36, culture supernatant

• Synonym(e): Anti-IDH, Anti-IDP, Anti-IDPC, Anti-Isocitrate dehydrogenase 1 (NADP+), soluble (IDH1), Anti-NADP+-specific ICDH, Anti-NADP-dependent isocitrate dehydrogenase, cytosolic, Anti-NADP-dependent isocitrate dehydrogenase, peroxisomal, Anti-Oxalosuccinate decarboxylase, Anti-PICD
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Konjugat: unconjugated
• Antikörperform: culture supernatant
• Antikörper-Produkttyp: primary antibodies
• Klon: IDH1-A36, monoclonal
• Form: aqueous solution
• Mol-Gew.: antigen predicted mol wt 46.7 kDa
• Speziesreaktivität: human
• Methode(n): western blot: suitable
• Isotyp: IgG1
• UniProt-Hinterlegungsnummer: O75874
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... IDH1(3417)

Beschreibung

Allgemeine Beschreibung

Isocitrate dehydrogenase 1 (IDH1) is encoded by the gene mapped to human chromosome 2q34. It is a member of the isocitrate dehydrogenase enzymes family. IDH1 is mainly found in cytoplasm and peroxisomes.

Immunogen

IDH1 purified recombinant protein

Biochem./physiol. Wirkung

Isocitrate dehydrogenase 1 (IDH1) acts as a regulator of cytoplasmic and peroxisomal lipid metabolism in various tissues. It catalyzes the conversion of isocitrate to α-ketoglutarate, which is a key cofactor for 2-OG-dependent dioxygenases. IDH1 facilitates various cellular processes such as adaptation to hypoxia, histone demethylation and DNA modification. It is also involved in the synthesis of plasmalogen lipids in peroxisomes. Somatic mutation of the gene is associated with the development of gliomas and acute myeloid leukaemia (AML).

Physikalische Form

Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable