SAB3500027

Anti-ZBED1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(e): Anti-ALTE, Anti-DREF, Anti-TRAMP, Anti-Zinc finger BED-type domain containing 1, Anti-hDREF
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Speziesreaktivität: human, mouse
• Methode(n): indirect ELISA: suitable; western blot: suitable
• NCBI-Hinterlegungsnummer: AAH15030
• UniProt-Hinterlegungsnummer: O96006
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... ZBED1(9189)

Beschreibung

Immunogen

ZBED1 antibody was raised against a 15 amino acid peptide from near the center of human ZBED1.

Leistungsmerkmale und Vorteile

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Zielbeschreibung

ZBED1, also known as DREF, is the human homolog of the Drosophila protein DREF, a transcriptional regulatory factor required for expression of genes involved in DNA replication and cell proliferation. RNA interference (RNAi) experiments targeting ZBED1 RNA resulted in the inhibition of S phase entry and reduction of histone H1 mRNA in HeLa cells, suggesting that ZBED1 also plays a role in cell proliferation in human cells. At least 22 ribosomal proteins (RPs) possess ZBED1 binding sites in their promoters; anti-ZBED1 RNAi also resulted in decreased RP gene expression. Immunoprecipitation analyses have shown that ZBED1 self-associates in vivo via a carboxyl-terminal hATC domain, and this self-association is required for nuclear localization and DNA binding. This antibody is predicted to have no cross-reactivity to ZBED2 or ZBED3.

Verlinkung

The action of this antibody can be blocked using blocking peptide SBP3500027.

Physikalische Form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable