SAB1403982

Monoclonal Anti-INS antibody produced in mouse

clone 7C8, purified immunoglobulin, buffered aqueous solution

• Synonym(e): ILPR, IRDN
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Konjugat: unconjugated
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 7C8, monoclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~1.65 kDa
• Speziesreaktivität: human
• Methode(n): indirect ELISA: suitable
• Isotyp: IgG3κ
• NCBI-Hinterlegungsnummer: NM_000207
• UniProt-Hinterlegungsnummer: P01308
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... INS(3630)

Beschreibung

Allgemeine Beschreibung

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5′ region and with the IGF2 gene at the 3′ region. (provided by RefSeq)

Immunogen

KLH-conjugated human Proinsulin peptide (NP_000198, 48 a.a. ~ 62 a.a)

Sequence
CFFYTPKTRREAEDLQ

Physikalische Form

Solution in phosphate buffered saline, pH 7.4

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable