SAB1306616

ANTI-PCM-1 (CENTER) antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

• Synonym(e): PCM1, Pericentriolar material 1 protein
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: 228533 Da
• Speziesreaktivität: human
• Methode(n): flow cytometry: 1:10-1:50; immunofluorescence: 1:10-1:50; immunohistochemistry: 1:50-1:100; western blot: 1:1000
• NCBI-Hinterlegungsnummer: NP_006188.3
• UniProt-Hinterlegungsnummer: Q15154
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... PCM1(5108)

Beschreibung

Allgemeine Beschreibung

Pericentriolar material 1 (PCM1) is a centriolar satellite protein. The PCM1 gene is located on the human chromosome at 8p22.

Biochem./physiol. Wirkung

Pericentriolar material 1 (PCM1) protein acts as a scaffold and facilitates the aggregation of target proteins to the centrosome during centrosome maturation. It forms a complex with Bardet-Biedl syndrome 4 protein (BBS4) and disrupted-in-schizophrenia 1 (DISC1) at the centrosome. PCM1 along with DISC1 and BBS4 plays a role in the centrosomal pathway that is associated with schizophrenia. It is involved in ciliogenesis by binding an E3 ligase enzyme to satellites. PCM1 regulates the primary cilia disassembly before mitotic entry by recruiting polo-like-kinase 1 (Plk1) to the pericentriolar matrix.

Physikalische Form

Supplied in PBS with 0.09% (W/V) sodium azide

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable