S6445

S-2E

≥98% (HPLC), powder

• Synonym(e): (S)-(+)-4-[1-(4-tert-Butylphenyl)-2-oxo-pyrrolidin-4-yl]methoxybenzoic acid
• Empirische Formel (Hill-System): C₂₂H₂₅NO₄
• CAS-Nummer: 155730-92-0
• Molekulargewicht: 367.44
• MDL-Nummer: MFCD06407742
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 24724620
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white
• Löslichkeit: DMSO: 11 mg/mL; H₂O: insoluble
• Lagertemp.: −20°C
• SMILES String: CC(C)(C)c1ccc(cc1)N2C[C@@H](COc3ccc(cc3)C(O)=O)CC2=O
• InChI: 1S/C22H25NO4/c1-22(2,3)17-6-8-18(9-7-17)23-13-15(12-20(23)24)14-27-19-10-4-16(5-11-19)21(25)26/h4-11,15H,12-14H2,1-3H3,(H,25,26)/t15-/m0/s1
• InChIKey: YZADMDZNVOBYGR-HNNXBMFYSA-N

Beschreibung

Anwendung

S-2E may be used in cell signaling studies.

Biochem./physiol. Wirkung

HMG-CoA reductase and acetyl-CoA carboxylase inhibitor.

HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. In the liver, S-2E is converted into its active metabolite, S-2E-CoA. S-2E-CoA noncompetitively inhibited the enzymatic activities of both 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase and acetyl-CoA carboxylase at K(i)=18.11 microM and K(i)=69.2 microM, respectively.

Verpackung

Shipped ambient under nitrogen.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)