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Merck
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Dokumente

S009

Sigma-Aldrich

LY-165,163

solid

Synonym(e):

4-[2-[4-[3-(Trifluoromethyl)phenyl]-1-piperazinyl]ethyl]benzeneamine, p-Aminophenethyl-m-trifluoromethylphenyl piperazine, PAPP

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About This Item

Empirische Formel (Hill-System):
C19H22F3N3
CAS-Nummer:
1814-64-8
Molekulargewicht:
349.39
MDL-Nummer:
MFCD00055098
UNSPSC-Code:
12352202
PubChem Substanz-ID:
24278123
NACRES:
NA.77

Form

solid

Farbe

off-white

Löslichkeit

0.1 M HCl: slightly soluble
H2O: insoluble
ethanol: freely soluble

SMILES String

Nc1ccc(CCN2CCN(CC2)c3cccc(c3)C(F)(F)F)cc1

InChI

1S/C19H22F3N3/c20-19(21,22)16-2-1-3-18(14-16)25-12-10-24(11-13-25)9-8-15-4-6-17(23)7-5-15/h1-7,14H,8-13,23H2

InChIKey

GAAKALASJNGQKD-UHFFFAOYSA-N

Angaben zum Gen

human ... HTR1A(3350) , HTR1D(3352)

Biochem./physiol. Wirkung

Selective 5-HT1A serotonin receptor agonist and 5-HT1D serotonin receptor antagonist.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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P H Hutson et al.
European journal of pharmacology, 143(2), 221-228 (1987-11-10)
The putative 5-HT1A agonist 1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine (LY165163, PAPP) (1, 2, 4, 10 mg/kg s.c.) caused a significant and dose-dependent hypothermia in rats, 30 and 60 min after injection. The decreases of temperature were less marked than that caused by 8-OH-DPAT 1
T P Donohoe et al.
Psychopharmacology, 93(1), 82-86 (1987-01-01)
The putative serotonin (5-HT)1A agonist 1-[2-(4-aminophenyl)ethyl]-4-(3-trifluormethylphenyl) piperazine (LY165163, PAPP) induces hyperphagia and hypothermia in rats, but unlike other 5-HT agonists, does not induce 5-HT stereotypy even at high doses (10 mg/kg sc). LY165163 (1 mg/kg) increased striatal DOPA accumulation in
M J Millan et al.
The Journal of pharmacology and experimental therapeutics, 269(1), 121-131 (1994-04-01)
In view of the involvement of central alpha 1-adrenoceptors in the expression of 5-HT1A receptor-mediated spontaneous tail-flicks (STFs) in the rat, this study examined whether the putative alpha 1-adrenoceptor antagonist (alpha 1-antagonist) properties of certain 5-HT1A receptor agonists, (+)-flesinoxan and
J S Sprouse et al.
Synapse (New York, N.Y.), 1(1), 3-9 (1987-01-01)
A direct comparison was made of the effects of serotonin 5-HT1A and 5-HT1B selective compounds on the spontaneous firing rate of dorsal raphe serotoninergic neurons in chloral-hydrate-anesthetized rats. Following intravenous administration, the 5-HT1A selective compounds ipsapirone (TVX Q 7821) and
J S Sprouse et al.
Neuropharmacology, 27(7), 707-715 (1988-07-01)
In low cerveau isolé transected rats, the effects of microiontophoretic application of putative serotonin 5-HT1A and 5-HT1B agonists on the spontaneous firing rate of CA1 pyramidal cells were compared to those of 5-HT. In contrast to the large current-dependent suppression
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