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RAB0161

Sigma-Aldrich

Phospho-EGFR (pSer1070) ELISA Kit

for detection of human, mouse or rat phospho-egfr (pSer1070) in cell and tissue lysates

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About This Item

UNSPSC-Code:
41116158
NACRES:
NA.32

Speziesreaktivität

mouse, human, rat

Methode(n)

ELISA: suitable
capture ELISA: suitable

Aufnahme

sample type tissue lysate
sample type cell lysate

Versandbedingung

wet ice

Lagertemp.

−20°C

Angaben zum Gen

human ... EGFR(1965)

Verwandte Kategorien

Allgemeine Beschreibung

The Human BLC ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human BLC in serum, plasma, cell culture supernatants and urine.
The EGFR (epidermal growth factor receptor) family includes four receptor tyrosine kinases, EGF R (ErbB1), ErbB2 (neu), ErbB3, and ErbB4. EGF R is present on many cell types of epithelial and mesenchymal lineages. The gene EGFR is mapped to human chromosome 7p11.2.

Immunogen

EGFR (pTyr1070) synthetic phosphopeptide

Anwendung

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem./physiol. Wirkung

The members of epidermal growth factor receptor (EGF R) or the ErbB receptor family have been identified as useful biomarkers and targets for cancer therapy. EGF R binds EGF and induces tyrosine phosphorylation leading to proliferation of cells. EGF R is capable of binding transforming growth factor-α and heparin-binding EGF in addition to EGF. There are numerous effector molecules activated by EGF R that result in a variety of biological processes such as morphogenesis, cell motility, apoptosis, differentiation and organ repair and maintenance. Deregulation of EGF R signaling is implicated in progression of a wide variety of tumors, invasion and metastasis. Phosphorylation of Tyr1068 occurs by autophosphorylation of EGF R and is required for the binding of Grb2 (Growth factor receptor-bound protein 2) and activation of ERK1/2 (extracellular signal-regulated kinases) pathway.

Piktogramme

CorrosionExclamation mark
GHS05,GHS07

Signalwort

Warning

H-Sätze

H290,H335

Gefahreneinstufungen

Met. Corr. 1 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

8A - Combustible corrosive hazardous materials

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5.
Lanzetti L, et al.
Nature, 408(6810), 374-374 (2000)
EGF receptor.
Wells A
The International Journal of Biochemistry & Cell Biology, 31(6), 637-643 (1999)
Landscape of EGFR signaling network in human cancers: biology and therapeutic response in relation to receptor subcellular locations.
Han W and Lo H W
Cancer Letters, 318(2), 124-134 (2012)
Targeting the EGFR signaling pathway in cancer therapy.
Seshacharyulu P, et al.
Expert Opinion on Therapeutic Targets, 16(1), 15-31 (2012)
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
Sanson M, et al.
Human Molecular Genetics, 20(14), 2897-2904 (2011)

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