R4393

Roxithromycin

95.0-102.0% (HPLC)

• Synonym(e): Erythromycin-9-[-O-(2-methoxyethoxy)-methyloxim]
• Empirische Formel (Hill-System): C₄₁H₇₆N₂O₁₅
• CAS-Nummer: 80214-83-1
• Molekulargewicht: 837.05
• MDL-Nummer: MFCD00214389
• UNSPSC-Code: 51282308
• PubChem Substanz-ID: 24899369
• NACRES: NA.85

Eigenschaften

• Assay: 95.0-102.0% (HPLC)
• Form: powder or crystals
• Löslichkeit: chloroform: soluble 10 mg/mL
• Wirkungsspektrum von Antibiotika: Gram-negative bacteria; Gram-positive bacteria
• Wirkungsweise: protein synthesis | interferes
• Lagertemp.: 2-8°C
• SMILES String: CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC3OC(C)CC(C3O)N(C)C)C(C)(O)CC(C)C(=N/OCOCCOC)\C(C)C(O)C1(C)O
• InChI: 1S/C41H76N2O15/c1-15-29-41(10,49)34(45)24(4)31(42-53-21-52-17-16-50-13)22(2)19-39(8,48)36(58-38-32(44)28(43(11)12)18-23(3)54-38)25(5)33(26(6)37(47)56-29)57-30-20-40(9,51-14)35(46)27(7)55-30/h22-30,32-36,38,44-46,48-49H,15-21H2,1-14H3/b42-31+
• InChIKey: RXZBMPWDPOLZGW-FEMONOMJSA-N

Beschreibung

Allgemeine Beschreibung

Chemical structure: macrolide

Anwendung

Roxithromycin is a semi-synthetic macrolide antibiotic. Roxithromycin is used to block bacterial protein synthesis. Clinically, it is used to treat respiratory tract, urinary and soft tissue infections. It has a similar antimicrobial spectrum as erythromycin, but is the preferred treatment for certain gram-negative bacteria, such as Legionella pneumophila.

Biochem./physiol. Wirkung

Roxithromycin impairs NADPH oxidase activation and alters translocation of its cytosolic components to the neutrophil membrane. It is similar in composition, chemical structure and mechanism of action to erythromycin, azithromycin, and clarithromycin. Roxithromycin binds to the subunit 50S of the bacterial ribosome, inhibiting the translocation of peptides.

Halbsynthetisches Erythromycinderivat. Beeinträchtigt die NADPH Oxidase Aktivierung und verändert die Translokation seiner cytosolischen Komponenten zur neutrophilen Membran.

Verpackung

1g,10g

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves