PZ0313

PF-04802367

≥98% (HPLC)

• Synonym(e): N-(3-(1H-1,2,4-Triazol-1-yl)propyl)-5-(3-chloro-4-methoxyphenyl)oxazole-4-carboxamide, PF 04802367, PF-367, PF-4802367
• Empirische Formel (Hill-System): C₁₆H₁₆ClN₅O₃
• CAS-Nummer: 1962178-27-3
• Molekulargewicht: 361.78
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329823833
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 20 mg/mL, clear
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• SMILES String: ClC1=CC(C2=C(C(NCCCN3N=CN=C3)=O)N=CO2)=CC=C1OC
• InChI: 1S/C16H16ClN5O3/c1-24-13-4-3-11(7-12(13)17)15-14(20-10-25-15)16(23)19-5-2-6-22-9-18-8-21-22/h3-4,7-10H,2,5-6H2,1H3,(H,19,23)
• InChIKey: RQFYFNAGNBUGFC-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

PF-04802367 (PF-367) is a potent and specific ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK-3α/β) with an IC₅₀ value of 2.3 nM and >450-fold selectivity for GSK-3 in a panel of >400 neuroreceptors, enzymes and kinases. GSK-3 dysregulation has been implicated in the pathogenesis of neurological diseases including Alzheimer′s disease.

PF-04802367 is also known as [N-(3-(1H-1,2,4-triazol-1-yl)propyl)-5-(3-chloro-4-methoxyphenyl)oxazole-4-carboxamide) or PF-367. It regulates tau phosphorylation in the brain.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable