P9864

PTP-β human

≥90%, recombinant, expressed in E. coli K12, GST-tagged, buffered aqueous glycerol solution, ≥50,000 units/mg protein

• Synonym(e): Protein Tyrosine Phosphatase-β
• CAS-Nummer: 300853-81-0
• MDL-Nummer: MFCD02688688
• UNSPSC-Code: 12352200
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human
• Qualitätsniveau: 200
• Rekombinant: expressed in E. coli K12
• Assay: ≥90%
• Form: buffered aqueous glycerol solution
• Spezifische Aktivität: ≥50,000 units/mg protein
• Mol-Gew.: ~250 kDa
• UniProt-Hinterlegungsnummer: P23467
• Anwendung(en): cell analysis
• Versandbedingung: dry ice
• Lagertemp.: −70°C
• Angaben zum Gen: human ... PTPRB(5787)

Beschreibung

Allgemeine Beschreibung

Protein tyrosine phosphatase, receptor type B (PTPRB), also known as vascular endothelial-protein-tyrosine phosphatase (VE-PTP), might have a role in remodeling of blood vessels and in angiogenesis. The gene encoding it is localized on human chromosome 12q15. It is also important for endothelial cell migration. The protein also controls the phosphorylation state of the angiopoietin receptor, Tie-2. PTPRB may modulate sodium channels by influencing the tyrosine phosphorylation status.

Biochem./physiol. Wirkung

Dephosphorylates tyrosine proteins.

Einheitendefinition

One unit of PTP-β will hydrolyze 1.0 nanomole of p-nitrophenyl phosphate per min at 30 °C.

Physikalische Form

solution in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCL, 3 mM DTT, 16 mM glutathione and 20% glycerol

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable