P4119

Polymyxin B -sulfat (Salz)

Biotechnology Performance Certified

• Empirische Formel (Hill-System): C₅₅H₉₆N₁₆O₁₃ · 2H₂SO₄
• CAS-Nummer: 1405-20-5
• Molekulargewicht: 1385.61
• EG-Nummer: 215-774-7
• MDL-Nummer: MFCD00131991
• UNSPSC-Code: 51101500

Eigenschaften

• Qualität: Biotechnology Performance Certified
• Form: powder
• Methode(n): cell culture | mammalian: suitable
• Verunreinigungen: endotoxin, tested
• Löslichkeit: H₂O: soluble 50 mg/mL
• Wirkungsspektrum von Antibiotika: Gram-negative bacteria; Gram-positive bacteria; fungi
• Wirkungsweise: cell membrane | interferes
• Lagertemp.: 2-8°C
• SMILES String: O=C(C(NC(C(CCN)NC(CCCCC(C)CC)=O)=O)C(C)O)NC(CCN)C(NC(CCNC(C(NC(C(NC(C(CCN)N1)=O)CCN)=O)C(O)C)=O)C(NC(CCN)C(NC(CC2=CC=CC=C2)C(NC(CC(C)C)C1=O)=O)=O)=O)=O.O=S(O)(O)=O
• InChI: 1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
• InChIKey: HNDFYNOVSOOGDU-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Chemical structure: peptide

Anwendung

Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa †. It also has uses studying multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.

Biochem./physiol. Wirkung

Wirkungsweise: Polymyxin-B-Sulfat bindet an den Lipid-A-Teil der bakteriellen Lipopolysaccharide† und unterbricht die Zytoplasmamembran durch Bildung von Poren, die groß genug sind, um einen Nukleotidaustritt durch die Bakterienwände zu ermöglichen. Dadurch wird die Durchlässigkeit der Zytoplasmamembran gestört.

Antimikrobielles Spektrum: Hat eine bakterizide Wirkung auf die meisten gramnegativen Stäbchen††, einschließlich E. coli, sowie auf die meisten Pilze und grampositiven Bakterien.

Vorsicht

As supplied, the product should be stored at 2-8°C in the dark. No change was observed in retained samples after three years′ of storage in these conditions. Stock solutions should be sterile filtered and stored at 2-8°C. They are stable at 37°C for 5 days.

Angaben zur Herstellung

Polymyxin B sulfate is soluble in water at 50 mg/mL, producing a very slightly hazy, colorless to yellow solution. It has only minimal solubility in any organic solvent. For example, it has a solubility of 0.115 mg/mL in ethanol. This product is biotechnology performance certified.

Sonstige Hinweise

10mu,25mu,50mu

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves