P0999

Anti-Potassium Channel K_v10.1 (EAG-1) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• Synonym(e): Anti-Ether-a-go-go K⁺ channel 1, Anti-KCNH1
• MDL-Nummer: MFCD08705506
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: lyophilized powder
• Speziesreaktivität: human, mouse, rat
• Methode(n): western blot: 1:200 using rat brain lysate and transfected cells HEK-K_V10.1.
• UniProt-Hinterlegungsnummer: O95259
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... KCNH1(3756) ; mouse ... Kcnh1(16510) ; rat ... Kcnh1(65198)

Beschreibung

Allgemeine Beschreibung

Human genome codes for 40 voltage-gated K⁺ channels (K_V). Voltage-gated-like ion channels (VGICs) are the third largest group of signaling molecules found in humans. K⁺ channels can be divided into four structural types based on their number of transmembrane regions and mode of activation, namely K_ir- the inwardly rectifying 2-transmembrane K⁺ channels, K_2P- 2-pore 4-transmembrane K⁺ channels, K_Ca- Ca²⁺-activated 6-transmembrane or 7-transmembrane K⁺ channels, and K_V- voltage-gated 6-transmembrane K⁺ channels. KCNH1 (potassium voltage-gated channel H1) is a K_V channel and is also known as K_V10.1. Like all K_V members, it is composed of four α-subunits with each containing six transmembrane α-helical segments, and a membrane-re-entering P-loop. These surround a central pore as homotetramers or heterotetramers. KCNH1 mRNA and protein are both abundantly found in the brain, though its peripheral tissue expression is restricted. This gene is localized to human chromosome 1q32.1.

Spezifität

Specific for K_V10.1 and does not cross react with K_V10.2.

Immunogen

peptide GDPAKRKGWARFKDAC corresponding to residues 802-817 of rat K_V10.1. This sequence is identical in mouse and has 14/16 residues identical in human.

Biochem./physiol. Wirkung

KCNH1 (potassium voltage-gated channel H1) initiates a slowly activating, non-inactivating K₊ current in a heterologous system. In skeletal muscles, it is expressed only during the phase when myoblasts exit the cell cycle and fuse, and thus, it plays an essential role in skeletal muscle development. This protein is found to be expressed in ∼70% human cancers, including gastric, mammary tumors, colon carcinoma, and sarcomas. This channel is implicated in neuronal disorders such as Zimmermann-Laband and Temple-Baraitser syndromes.

Zielbeschreibung

Potassium Channel K_v10.1 (EAG-1) encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming α-subunit of a voltage-gated non-inactivating delayed rectifier potassium channel.

Physikalische Form

Lyophilized from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable