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P0248

Sigma-Aldrich

PNU-37883A

≥98% (HPLC), powder

Synonym(e):

N-(1-Adamantyl)-N′-cyclohexyl-4-morpholinecarboxamidine hydrochloride

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About This Item

Empirische Formel (Hill-System):
C21H36ClN3O
CAS-Nummer:
57568-80-6
Molekulargewicht:
381.98
MDL-Nummer:
MFCD06798347
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24277692

Assay

≥98% (HPLC)

Form

powder

Farbe

white

Löslichkeit

DMSO: ~23 mg/mL
H2O: insoluble

Lagertemp.

2-8°C

SMILES String

Cl.C1CCC(CC1)\N=C(/NC23CC4CC(CC(C4)C2)C3)N5CCOCC5

Angaben zum Gen

human ... KCNJ8(3764)

Biochem./physiol. Wirkung

Selective inhibitor of Kir6.1/SUR2B channels.

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Cheng-Yuan Hsu et al.
Shock (Augusta, Ga.), 37(6), 653-658 (2012-05-04)
In clinical practice, prolonged occlusion of main arteries causes accumulation of metabolic waste and lactate. Reperfusion of blood flow is usually accompanied by circulatory shock. This study investigates the molecular mechanisms responsible for acidosis-induced hypotension and proposes therapeutic strategies for
Yoshihiro Suzuki et al.
International journal of oncology, 41(2), 465-475 (2012-05-23)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is promising for cancer treatment owing to its selective cytotoxicity against malignant cells. However, some cancer cell types, including malignant melanoma cells, are resistant to TRAIL-induced apoptosis. Therefore, drugs that can amplify TRAIL cytotoxicity
Salma Toma Hanna et al.
European journal of pharmacology, 515(1-3), 34-42 (2005-05-17)
Kir6.1 subunit is one of the pore-forming components of K(ATP) channel complex. The endogenous modulation of Kir6.1 subunit function has been largely unknown. Whether acetylcholine modulated the function of Kir6.1 subunit stably expressed in human embryonic kidney (HEK-293) cells was
Toshihisa Tomoda et al.
European journal of pharmacology, 524(1-3), 1-10 (2005-10-26)
The effects of U-37883A, a vascular ATP-sensitive K(+) channel (K(ATP) channel) blocker, on membrane currents were investigated in pig urethral myocytes by use of patch-clamp techniques (conventional whole-cell recordings, nystatin-perforated patches and cell-attached configuration). Tension measurement was also performed to
Bo Jiang et al.
European journal of pharmacology, 577(1-3), 124-128 (2007-10-24)
Sulphonylureas, such as glybenclamide and gliclazide, are classical blockers of ATP-dependent potassium channels (K(ATP)). Closure of K(ATP) channels in vascular smooth muscles by sulphonylureas would lead to membrane depolarization and vasoconstriction but this hypothesis has not been consistently proved in
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