O4375

Oxytocin

lyophilized powder, ~15 IU/mg solid (Prepared from synthetic oxytocin)

• Synonym(e): α-Hypophamin, Ocytocin
• Empirische Formel (Hill-System): C₄₃H₆₆N₁₂O₁₂S₂
• CAS-Nummer: 50-56-6
• Molekulargewicht: 1007.19
• Beilstein: 3586108
• MDL-Nummer: MFCD00076731
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 24897994
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: synthetic
• Sterilität: non-sterile
• Form: lyophilized powder
• Spezifische Aktivität: ~15 IU/mg solid (Prepared from synthetic oxytocin)
• Löslichkeit: water: 10 mg/mL, clear, colorless
• UniProt-Hinterlegungsnummer: P01178; P30559; P70536
• Versandbedingung: ambient
• Lagertemp.: 2-8°C
• SMILES String: [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)[C@@H](C)CC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O
• InChI: 1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1
• InChIKey: XNOPRXBHLZRZKH-DSZYJQQASA-N
• Angaben zum Gen: human ... OXT(5020) , OXTR(5021) ; rat ... Oxtr(25342)

Beschreibung

Amino Acid Sequence

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 [Disulfide Bridge: 1-6]

Allgemeine Beschreibung

Oxytocin (OXT) is a potent natriuretic hormone encoded by the gene mapped to human chromosome 20p13. It is synthesized along with its carrier protein neurophysin I from its inactive precursor prepro-OXT. OXT gene consists of three exons and two introns where first exon codes for hormone OXT while other exon codes for neurophysin I.

Anwendung

Oxytocin has been used in immunocytochemistry analysis and it has also been used to study the mechanism responsible for the reduced ability of mice deficient in plasminogen (Plg) to support a litter during lactation.

Biochem./physiol. Wirkung

Oxytocin (OXT) and arginine vasopressin hormone plays a vital role in regulation of water excretion, parturition and lactation. OXT has been implicated in hydromineral homeostasis and vascular and cardiac relaxation. Oxytocin might function as an effective therapeutic for psychiatric diseases, including depression, schizophrenia, anxiety disorders and autism. OXT has a potential as a marker of autism severity. OXT is an anorexigenic neuropeptide, which is implicated in social cognition and obsessive-compulsive behavior. Plasma oxytocin levels are high in children with Prader-willi syndrome (PWS) compared with unrelated and unaffected siblings. Deficiency of OXT hormone might contribute to pathogenesis of attention deficit/hyperactivity disorder (ADHD).

Stimuliert Uteruskontraktion und Milchbildung; erhöht die Na⁺-Ausscheidung; stimuliert myometriale GTPase und Phospholipase  C.

Physikalische Form

Lyophilized powder containing 3% oxytocin with mannitol and buffer salts.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable