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N8381

Sigma-Aldrich

2-Naphthylamin

powder

Synonym(e):

β-Naphthylamin, 2-Amino-naphthalin

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About This Item

Lineare Formel:
C10H7NH2
CAS-Nummer:
91-59-8
Molekulargewicht:
143.19
Beilstein:
3939429
EG-Nummer:
202-080-4
MDL-Nummer:
MFCD00004112
UNSPSC-Code:
12352103
PubChem Substanz-ID:
24897863
NACRES:
NA.25

Form

powder

bp

306 °C (lit.)

mp (Schmelzpunkt)

111-113 °C (lit.)

Dichte

1.061 g/mL at 25 °C (lit.)

SMILES String

Nc1ccc2ccccc2c1

InChI

1S/C10H9N/c11-10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,11H2

InChIKey

JBIJLHTVPXGSAM-UHFFFAOYSA-N

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Allgemeine Beschreibung

2-Naphthylamine is a bladder carcinogen, which is mainly present in cigarette smoke.

Anwendung

2-Naphthylamine has been used as a substrate for measuring aminopeptidase A and aminopeptidase N activity.

Biochem./physiol. Wirkung

Environmental carcinogen; induces bladder cancer.

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 1A

Lagerklassenschlüssel

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Persönliche Schutzausrüstung

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Analysenzertifikate (COA)

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1-Naphthylamine for synthesis

Sigma-Aldrich

8.22291

1-Naphthylamine

2-Aminoanthracen 96%

Sigma-Aldrich

A38800

2-Aminoanthracen

4-Methoxy-2-naphthylamin ≥98%

Sigma-Aldrich

M9894

4-Methoxy-2-naphthylamin

9-Aminophenanthren 96%

Sigma-Aldrich

149101

9-Aminophenanthren

1-Aminopyren 97%

Sigma-Aldrich

A77903

1-Aminopyren

Y Yasunaga et al.
Laboratory investigation; a journal of technical methods and pathology, 77(6), 677-684 (1998-01-14)
Epidemiologic studies have revealed an increased risk for development of transitional cell carcinoma (TCC) among dye workers/painters occupationally exposed to aromatic amines such as benzidine, beta-naphthylamine, orthotoluidine, and aniline. In the present study, p53 gene mutations in 26 patients with
Shiho Ohnishi et al.
Japanese journal of cancer research : Gann, 93(7), 736-743 (2002-08-01)
2-Naphthylamine (2-NA), a bladder carcinogen, is contained in cigarette smoke. DNA adduct formation is thought to be a major cause of DNA damage by carcinogenic aromatic amines. We have investigated whether a metabolite of 2-NA, 2-nitroso-1-naphthol (NO-naphthol) causes oxidative DNA
A Fernández-Atucha et al.
Biology of sex differences, 8, 5-5 (2017-02-09)
Serum peptidases, such as angiotensin-converting enzyme (ACE), angiotensin-converting enzyme-2 (ACE2), neutral endopeptidase (NEP), aminopeptidase N (APN), and aminopeptidase A (APA), are important elements of the renin-angiotensin system (RAS). Dysregulation of these enzymes has been associated with hypertension and cardiovascular risk.
Dylan M Owen et al.
Nature communications, 3, 1256-1256 (2012-12-06)
Lipid microdomains are postulated to regulate many membrane-associated processes but have remained highly controversial. Here we provide the first direct evidence that the plasma membrane of intact, live cells is comprised of a sub-resolution mixture of approximately 76% ordered and
Carlos de la Haba et al.
Biochimica et biophysica acta, 1828(2), 357-364 (2012-09-04)
Plasma membrane is one of the preferential targets of reactive oxygen species which cause lipid peroxidation. This process modifies membrane properties such as membrane fluidity, a very important physical feature known to modulate membrane protein localization and function. The aim
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