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N8161

Sigma-Aldrich

NS309

≥98% (HPLC), solid

Synonym(e):

3-Oxime-6,7-dichloro-1H-indole-2,3-dione

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About This Item

Empirische Formel (Hill-System):
C8H4Cl2N2O2
CAS-Nummer:
18711-16-5
Molekulargewicht:
231.04
MDL-Nummer:
MFCD06798346
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329818681
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

solid

Farbe

yellow

Löslichkeit

DMSO: 22 mg/mL

Lagertemp.

2-8°C

SMILES String

O\N=C1\C(=O)Nc2c(Cl)c(Cl)ccc12

InChI

1S/C8H4Cl2N2O2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12-14/h1-2,14H,(H,11,12,13)

InChIKey

CVOUSAVHMDXCKG-UHFFFAOYSA-N

Biochem./physiol. Wirkung

NS309 is a Ca2+-activated IK/SK potassium channel activator.

Leistungsmerkmale und Vorteile

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Vorsicht

air sensitive

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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Fan-Fan Li et al.
Placenta, 58, 9-16 (2017-10-01)
Excessive constriction of placental chorionic plate arteries (CPAs) may be associated with preeclampsia (PE). Nitric oxide (NO) as well as intermediate and small Ca The location of IK IK This study provides evidence that dysregulated IK
Monika Kloza et al.
Vascular pharmacology, 99, 65-73 (2017-10-19)
The aim of this study was to examine the influence of deoxycorticosterone acetate-salt (DOCA-salt) hypertension and chronic treatment with the fatty acid amide hydrolase inhibitor, URB597, on small and intermediate conductance calcium-activated potassium channels and endothelium-dependent hyperpolarization (K
Abbie C Johnson et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 37(8), 2857-2869 (2016-11-07)
We investigated the effect of experimental preeclampsia on hyperemia during seizure in the hippocampus and vascular function and structure of hippocampal arterioles using Sprague Dawley rats (n = 14/group) that were nonpregnant, pregnant (d20), or had experimental preeclampsia (induced by a high
Jackson T Fontaine et al.
Mechanisms of ageing and development, 192, 111389-111389 (2020-11-01)
Vascular cognitive impairment, the second most common cause of dementia, profoundly affects hippocampal-dependent functions. However, while the growing literature covers complex neuronal interactions, little is known about the sustaining hippocampal microcirculation. Here we examined vasoconstriction to physiological pressures of hippocampal
Jensen, B.S., et al.
Abstr. Soc. Neurosci, 2003, 367-367 null
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