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N2019

Sigma-Aldrich

Nogalamycin

≥95%, from Streptomyces nogalater

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About This Item

Empirische Formel (Hill-System):
C39H49NO16
CAS-Nummer:
1404-15-5
Molekulargewicht:
787.80
MDL-Nummer:
MFCD00083442
UNSPSC-Code:
51111755
PubChem Substanz-ID:
24897545

Biologische Quelle

Streptomyces nogalater

Assay

≥95%

Form

solid

Wirkungsspektrum von Antibiotika

neoplastics

Wirkungsweise

DNA synthesis | interferes
enzyme | inhibits

Lagertemp.

2-8°C

SMILES String

COC1C(C)OC(OC2CC(C)(O)C(C(=O)OC)c3cc4C(=O)c5c6OC7OC(C)(C(O)C(C7O)N(C)C)c6cc(O)c5C(=O)c4c(O)c23)C(OC)C1(C)OC

InChI

1S/C39H49NO16/c1-14-32(49-7)39(4,52-10)33(50-8)36(53-14)54-19-13-37(2,48)24(34(47)51-9)15-11-16-21(27(43)20(15)19)28(44)22-18(41)12-17-30(23(22)26(16)42)55-35-29(45)25(40(5)6)31(46)38(17,3)56-35/h11-12,14,19,24-25,29,31-33,35-36,41,43,45-46,48H,13H2,1-10H3

InChIKey

KGTDRFCXGRULNK-UHFFFAOYSA-N

Biochem./physiol. Wirkung

Anthracyclic antitumor antibiotic.
Anthracyclic antitumor antibiotic. It is used as a sequence specific DNA binding (intercalation) reagent, binds d(CGTACG), d(ATGCAT).

Sonstige Hinweise

50mg
Keep container tightly closed in a dry and well-ventilated place.Light sensitive.

Piktogramme

Health hazardExclamation mark
GHS08,GHS07

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 4 Oral - Carc. 1B - Repr. 1B

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Priyanka Sharma et al.
Scientific reports, 10(1), 4104-4104 (2020-03-07)
Actinobacteria is a goldmine for the discovery of abundant secondary metabolites with diverse biological activities. This study explores antimicrobial biosynthetic potential and diversity of actinobacteria from Pobitora Wildlife Sanctuary and Kaziranga National Park of Assam, India, lying in the Indo-Burma
Philipp Beinker et al.
Journal of molecular biology, 359(3), 728-740 (2006-05-03)
SnoaL2 and AclR are homologous enzymes in the biosynthesis of the aromatic polyketides nogalamycin in Streptomyces nogalater and cinerubin in Streptomyces galilaeus, respectively. Evidence obtained from gene transfer experiments suggested that SnoaL2 catalyzes the hydroxylation of the C-1 carbon atom
Magnus Claesson et al.
The FEBS journal, 279(17), 3251-3263 (2012-07-19)
The glycosyltransferase SnogD from Streptomyces nogalater transfers a nogalamine moiety to the metabolic intermediate 3',4'-demethoxynogalose-1-hydroxynogalamycinone during the final steps of biosynthesis of the aromatic polyketide nogalamycin. The crystal structure of recombinant SnogD, as an apo-enzyme and with a bound nucleotide
Tuan-Nghia Phan et al.
European journal of biochemistry, 270(8), 1735-1745 (2003-04-16)
A novel ATP-dependent nuclear DNA unwinding enzyme from pea has been purified to apparent homogeneity and characterized. This enzyme is present at extremely low abundance and has the highest specific activity among plant helicases. It is a heterodimer of 54
L H Li et al.
Pharmacology & therapeutics, 51(2), 239-255 (1991-01-01)
This review assimilates up-to-date information on the biochemical pharmacology of nogalamycin and selected derivatives that have shown good biological activities and/or received a relatively detailed investigation. The structure and chemical preparation of these derivatives from nogalamycin is described and the
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