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MAK071

Sigma-Aldrich

Pyruvate Assay Kit

sufficient for 100 colorimetric or fluorometric tests

Synonym(e):

Assay Kit for Pyruvate Detection

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About This Item

UNSPSC-Code:
12161503
NACRES:
NA.84

Verwendung

sufficient for 100 colorimetric or fluorometric tests

Nachweisverfahren

colorimetric
fluorometric

Relevante Krankheit(en)

gastrointestinal diseases; cancer

Lagertemp.

−20°C

Angaben zum Gen

human ... PKLR(5313) , PKM2(5315)
mouse ... PKLR(18770) , PKM2(18746)
rat ... PKLR(24651) , PKM2(25630)

Allgemeine Beschreibung

Pyruvate is a central molecule in metabolism that is used and synthesized through multiple metabolic pathways including glycolysis and the transamination of alanine. Pyruvate may be further oxidized in the citric acid cycle, converted to carbohydrates during gluconeogenesis, or reduced to lactate. High levels of pyruvate are associated with liver disease and genetic disorders. Pyruvate has also been used to stimulate metabolism leading to loss of body weight.

Eignung

Suitable for measuring pyruvate concentration in various biological samples such as blood, tissues, and culture cells.

Prinzip

Pyruvate concentration is determined by a coupled enzyme assay, which results in a colorimetric (570 nm)/fluorometric (λex = 535/λem = 587 nm) product, proportional to the pyruvate present.

Ersetzt durch

Produkt-Nr.
Beschreibung
Preisangaben

Piktogramme

Health hazard
GHS08

Signalwort

Danger

Gefahreneinstufungen

Aquatic Chronic 3 - Resp. Sens. 1 - Skin Sens. 1

Lagerklassenschlüssel

10 - Combustible liquids

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De Palma S, et al.
PLoS ONE, 8(2), e56716-e56716 (2013)
Abstracts of the XVIth International Conference on Biological Inorganic Chemistry, July 22-26, 2013, Grenoble, France.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 19 Suppl 1, 1-696 (2014-03-13)
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