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M1695

MAZ51

Name: MAZ51
Brand: SIGMA

≥98% (HPLC), solid

Synonym(e):

3-(4-Dimethylaminonaphthalen-1-ylmethylene)-1,3-dihydroindol-2-one

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About This Item

Empirische Formel (Hill-System):

C₂₁H₁₈N₂O

CAS-Nummer:

163655-37-6

Molekulargewicht:

314.38

MDL-Nummer:

MFCD04036983

UNSPSC-Code:

12352200

PubChem Substanz-ID:

24724533

Assay

≥98% (HPLC)

Form

solid

Farbe

orange

Löslichkeit

DMSO: 11 mg/mL

Lagertemp.

2-8°C

SMILES String

CN(C)c1ccc(\C=C2/C(=O)Nc3ccccc23)c4ccccc14

Biochem./physiol. Wirkung

Cell-permeable VEGFR-3 inhibitor. At low concentration ≥ 5 μM), it specifically blocks VEGF-C- and VEGF-D-induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells. It partially blocks VEGFR-2 phosphorylation only at higher concentrations (50 μM).

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Restoration of natural killer cell cytotoxicity by VEGFR-3 inhibition in myelogenous leukemia.

Ji Yoon Lee et al.

Cancer letters, 354(2), 281-289 (2014-08-27)

Acute myeloid leukemia (AML) cells in vivo are constantly exposed to lymphangiogenic cytokines such as VEGF-C. However, it is poorly understood how the VEGF-C signaling modulates the immune functions in the tumor microenvironment. We have previously reported that natural killer

Lymphangiogenesis is induced by mycobacterial granulomas via vascular endothelial growth factor receptor-3 and supports systemic T-cell responses against mycobacterial antigen.

Jeffrey Harding et al.

The American journal of pathology, 185(2), 432-445 (2015-01-20)

Granulomatous inflammation is characteristic of many autoimmune and infectious diseases. The lymphatic drainage of these inflammatory sites remains poorly understood, despite an expanding understanding of lymphatic role in inflammation and disease. Here, we show that the lymph vessel growth factor

Endothelial Snail Regulates Capillary Branching Morphogenesis via Vascular Endothelial Growth Factor Receptor 3 Expression.

Jeong Ae Park et al.

PLoS genetics, 11(7), e1005324-e1005324 (2015-07-07)

Vascular branching morphogenesis is activated and maintained by several signaling pathways. Among them, vascular endothelial growth factor receptor 2 (VEGFR2) signaling is largely presented in arteries, and VEGFR3 signaling is in veins and capillaries. Recent reports have documented that Snail

The indolinone MAZ51 induces cell rounding and G2/M cell cycle arrest in glioma cells without the inhibition of VEGFR-3 phosphorylation: involvement of the RhoA and Akt/GSK3β signaling pathways.

Joo-Hee Park et al.

PloS one, 9(9), e109055-e109055 (2014-10-01)

MAZ51 is an indolinone-based molecule originally synthesized as a selective inhibitor of vascular endothelial growth factor receptor (VEGFR)-3 tyrosine kinase. This study shows that exposure of two glioma cell lines, rat C6 and human U251MG, to MAZ51 caused dramatic shape

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