L4295

LDN-91946

≥98% (HPLC)

• Synonym(e): 3-Amino-2-benzoyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid
• Empirische Formel (Hill-System): C₁₅H₁₀N₂O₄S
• CAS-Nummer: 439946-22-2
• Molekulargewicht: 314.32
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: protect from light
• Farbe: brown
• Löslichkeit: DMSO: ≥10 mg/mL
• Lagertemp.: 2-8°C

Beschreibung

Biochem./physiol. Wirkung

LDN-91946 is a potent, selective and uncompetitive UCH-L1 inhibitor that targets the enzyme-substrate complex, but not the free enzyme. Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme. It is one of the most abundant proteins in the brain. UCKL1 plays a key role in processing polyubiquitin and ubiquitylated proteolytic peptides. The enzyme has been linked to Parkinson disease and lung cancer. LDN-91946 inhibits UCH-L1-catalyzed substrate hydrolysis in an uncompetitive manner by targeting the enzyme-substrate complex, but not the free enzyme. The compound is quite specific and is exhibiting little activity against UCH-L3, TGase 2, Papain, or Caspase-3 even at concentrations as high as 20 μM. Compound was recently launched by Calbiochem. LDN-57444 is acts as competitive inhibitor.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable