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L4021

Sigma-Aldrich

Prolaktin human

recombinant, expressed in E. coli, lyophilized powder, BioReagent, suitable for cell culture, >97% (SDS-PAGE)

Synonym(e):

hPRL, LTH, Lactogenic Hormone, Luteotropic Hormone, PRL

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About This Item

CAS-Nummer:
9002-62-4
MDL-Nummer:
MFCD00131553
UNSPSC-Code:
51111800
NACRES:
NA.77

Rekombinant

expressed in E. coli

Qualitätsniveau

200

Beschreibung

200 amino acid residue methionyl form of mature, recombinant human prolactin (amino acid residues 29-227).

Produktlinie

BioReagent

Assay

>97% (SDS-PAGE)

Form

lyophilized powder

Wirksamkeit

0.030-0.300 ng/mL EC50

Mol-Gew.

predicted mol wt ~24 kDa

Methode(n)

cell culture | mammalian: suitable

Verunreinigungen

endotoxin, tested

Löslichkeit

water: 0.5000 mL, clear, colorless

UniProt-Hinterlegungsnummer

P01236

Versandbedingung

ambient

Lagertemp.

−20°C

Angaben zum Gen

human ... PRL(5617)

Anwendung

Use in cell culture applications to study prolactin regulation of cell signaling and gene expression.

Biochem./physiol. Wirkung

Prolactin is a neuroendocrine hormone. The prolactin receptor is a transmembrane glycoprotein that belongs to the cytokine hematopoietic receptor family. A large number of cells and organs express the receptor, including B cells, T cells, macrophages, monocytes, and neutrophils. Prolactin signal transduction involves the JAK/STAT families and the src kinase family. Induces lactation; inhibits secretion of gonadotropins; release is inhibited by dopamine.

Sonstige Hinweise

Contains an N-terminal methionine not present in the natural product.

Physikalische Form

Lyophilized from a solution in 10 mM phosphate and 50 mM sodium chloride, pH 8.0.

Rekonstituierung

It is recommended that sterile 4 mM HCl containing 1 mg/mL bovine serum albumin be added to the vial to prepare a stock solution of no less than 100 μg/mL.

Hinweis zur Analyse

The biological activity is assayed by proliferation of the rat lymphoma cell line, Nb2-11.

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H360

Gefahreneinstufungen

Repr. 1B

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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G Bellone et al.
Journal of cellular physiology, 163(2), 221-231 (1995-05-01)
The pituitary hormone prolactin (Prl) is known to act as a local regulator of immune cell function, and Prl-binding receptors (Prl-R) have been described to share distinctive features with the members of the newly described cytokine/hemopoietin receptor superfamily. Here we
Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects.
N Ben-Jonathan et al.
Endocrine reviews, 17(6), 639-669 (1996-12-01)
Julien Auffret et al.
American journal of physiology. Endocrinology and metabolism, 305(10), E1309-E1318 (2013-09-26)
Prolactin (PRL) and placental lactogens stimulate β-cell replication and insulin production in pancreatic islets and insulinoma cells through binding to the PRL receptor (PRLR). However, the contribution of PRLR signaling to β-cell ontogeny and function in perinatal life and the
Massimo Costanza et al.
Journal of immunology (Baltimore, Md. : 1950), 191(5), 2082-2088 (2013-07-26)
Predominance of multiple sclerosis (MS) in women, reductions of disease flares during pregnancy, and their increase in the postpartum period have suggested a hormonal influence on MS activity. The hormone prolactin (PRL) has long been debated as a potential immune-stimulating
Gerda de Kuijper et al.
Research in developmental disabilities, 34(9), 2799-2809 (2013-06-25)
Individuals with intellectual disability frequently use antipsychotics for many years. This may have detrimental health effects, including neurological symptoms and metabolic and hormonal dysregulation, the latter possibly affecting bone metabolism. There is large variability in the degree in which antipsychotic
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