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L3042

Sigma-Aldrich

Levostin

≥99% (HPLC), solid

Synonym(e):

Levocabastin -hydrochlorid, Levophta, R50547, [3S-[1(cis),3α,4β]]-1-[4-cyano-4-(4-fluorphenyl)cyclohexyl]-3-methyl-4-phenyl-4-piperidincarbonsäure

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About This Item

Empirische Formel (Hill-System):
C26H29N2O2F·HCl
CAS-Nummer:
79547-78-7
Molekulargewicht:
456.98
MDL-Nummer:
MFCD07787408
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329817402

Assay

≥99% (HPLC)

Form

solid

Farbe

white

Löslichkeit

DMSO: soluble ~10 mg/mL

Ersteller

Johnson & Johnson

SMILES String

Cl[H].C[C@@H]1CN(CC[C@]1(C(O)=O)c2ccccc2)[C@@H]3CC[C@@](CC3)(C#N)c4ccc(F)cc4

InChI

1S/C26H29FN2O2.ClH/c1-19-17-29(16-15-26(19,24(30)31)21-5-3-2-4-6-21)23-11-13-25(18-28,14-12-23)20-7-9-22(27)10-8-20;/h2-10,19,23H,11-17H2,1H3,(H,30,31);1H/t19-,23-,25-,26-;/m1./s1

InChIKey

OICFWWJHIMKBCD-VALQNVSPSA-N

Angaben zum Gen

human ... HRH1(3269)

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Biochem./physiol. Wirkung

Non-peptide histamine H1 receptor antagonist; neurotensin NTS2 receptor ligand.

Leistungsmerkmale und Vorteile

This compound is featured on the Neurotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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Sigma-Aldrich

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M Boules et al.
Brain research, 1294, 22-28 (2009-08-05)
Neurotensin (NT) is a neuropeptide with antinociceptive effects that are mediated through NT receptors, of which there are three known subtypes (NTS1, NTS2, and NTS3). Morphine is a mu-opioid receptor agonist commonly used for pain treatment but is associated with
A Leonardi et al.
The British journal of ophthalmology, 91(12), 1662-1666 (2007-06-23)
This comparative and randomised pilot study assessed the clinical and biological efficacy of Naaxia Sine(R) eye-drops versus levocabastine eye-drops in the treatment of vernal keratoconjunctivitis (VKC). Twenty-three VKC patients were randomised and treated bilaterally for 28 days with N-acetyl-aspartyl-glutamate (NAAGA)
Geneviève Roussy et al.
Molecular pain, 5, 38-38 (2009-07-08)
Central neurotensin (NT) administration results in a naloxone-insensitive antinociceptive response in animal models of acute and persistent pain. Both NTS1 and NTS2 receptors were shown to be required for different aspects of NT-induced analgesia. We recently demonstrated that NTS2 receptors
Bernd Lange et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 95(3), 272-282 (2005-10-05)
Current guidelines recommend intranasal glucocorticosteroids as first-line therapy for seasonal allergic rhinitis. To compare the efficacy, cost-effectiveness, and tolerability of the topical glucocorticosteroid mometasone furoate, the topical antihistamine levocabastine hydrochloride, and the cromone disodium cromoglycate in seasonal allergic rhinitis. This
Ahmed R Qasem et al.
Biochemical pharmacology, 76(6), 751-762 (2008-08-06)
Levocabastine is an antiallergic drug acting as a histamine H1-receptor antagonist. In allergic conjunctivitis (AC), it may also antagonize up-regulation of the intercellular adhesion molecule-1 (ICAM-1) expressed on epithelial conjunctival cells. However, little is known about its effects on eosinophils
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