J4205

JK184

≥98% (HPLC), powder

• Synonym(e): N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine
• Empirische Formel (Hill-System): C₁₉H₁₈N₄OS
• CAS-Nummer: 315703-52-7
• Molekulargewicht: 350.44
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 329815733
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: off-white to light brown
• Löslichkeit: DMSO: ≥20 mg/mL
• Lagertemp.: room temp
• SMILES String: CCOc1ccc(Cc2nc(cs2)-c3c(C)nc4ccccn34)cc1
• InChI: 1S/C20H19N3OS/c1-3-24-16-9-7-15(8-10-16)12-19-22-17(13-25-19)20-14(2)21-18-6-4-5-11-23(18)20/h4-11,13H,3,12H2,1-2H3
• InChIKey: CBKFVRMNQUKWPX-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

JK184 is a Hedgehog signaling pathway antagonist. JK184 blocks sonic hedgehog induced Gli transcription with an IC50 of 30 nM, and disrupts hedgehog signalling by inhibition of alcohol dehydrogenase 7 and depolymerization of mirotubules.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3