J3580

JNJ 17203212

≥98% (HPLC)

• Synonym(e): N¹-(3-Trifluoromethylpyrid-2-yl)-N⁴-(4-trifluoromethylpyrid-2-yl)carbamoylpiperazine
• Empirische Formel (Hill-System): C₁₇H₁₅F₆N₅O
• CAS-Nummer: 821768-06-3
• Molekulargewicht: 419.32
• UNSPSC-Code: 12352200

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to off-white
• Löslichkeit: DMSO: >20 mg/mL
• Ersteller: Johnson & Johnson
• Lagertemp.: −20°C
• InChI: 1S/C17H15F6N5O/c18-16(19,20)11-3-4-13(25-10-11)26-15(29)28-8-6-27(7-9-28)14-12(17(21,22)23)2-1-5-24-14/h1-5,10H,6-9H2,(H,25,26,29)
• InChIKey: JFRYYGVYCWYIDQ-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

JNJ 17203212 is a reversible, competitive and potent TRPV1 antagonist that does not inhibit related TRP channels such as TRPV2, TRPV4, or TRPA1. Listed in BJP with IC50= 65 nM. TRPV1 channels are activated by heat, capsaicin and the endocannabinoid anandamide. Interest in TRPV1 antagonists in the transmission and modulation of pain.

Leistungsmerkmale und Vorteile

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301,H319
• P-Sätze: P301 + P310 + P330 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 3 Oral - Eye Irrit. 2
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable