I7389

Interleukin-3 human

IL-3, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• Synonym(e): hIL-3, IL-3
• MDL-Nummer: MFCD00147276
• UNSPSC-Code: 12352202

Eigenschaften

• Biologische Quelle: human
• Qualitätsniveau: 200
• Rekombinant: expressed in E. coli
• Assay: ≥95% (SDS-PAGE)
• Form: lyophilized powder
• Wirksamkeit: <0.5 ng/mL ED₅₀
• Qualität: endotoxin tested
• Verpackung: pkg of 4 μg
• Methode(n): cell culture | mammalian: suitable
• Verunreinigungen: <0.1 EU/μg
• UniProt-Hinterlegungsnummer: P08700
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... IL3(3562)

Beschreibung

Biochem./physiol. Wirkung

Interleukin-3 (IL-3) is a multifunctional protein, originally called colony forming unit-stimulating activity (CFU-SA), and is produced by activated T lymphocytes. IL-3 supports the formation of multilineage colonies in the early development of multipotent hematopoietic progenitor cells. IL-3 has been shown to induce colony formation of macrophages, neutrophils, mast cells, and megakaryocytes from agar-suspended bone marrow cells. IL-3 also interacts with IL-2 to stimulate growth of T lymphocytes and to induce IgG secretion from activated B cells. Other synonyms for IL-3 include pan-specific hemopoietin, multicolony stimulating factor, mast cell growth factor, burst promoting activity, histamine-producing cell stimulating factor, P cell stimulating factor, and WEHI-3 factor.

Einheitendefinition

One unit is the amount of IL-3 required to induce half-maximal incorportion of ³H thymidine. Activity also is expressed in Reference units (NIBSC reference preparation for IL-3 code 88/87).

Physikalische Form

Lyophilized from a 0.2 μm filtered solution.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)