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I7003
Ibogain -hydrochlorid
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About This Item
Empirische Formel (Hill-System):
C20H26N2O · HCl
CAS-Nummer:
Molekulargewicht:
346.89
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352200
Arzneimittelkontrolle
USDEA Schedule I; regulated under CDSA - not available from Sigma-Aldrich Canada
Löslichkeit
H2O: soluble
methanol: soluble
Anwendung(en)
forensics and toxicology
SMILES String
Cl.CCC1CC2CC3C1N(CCc4c3[nH]c5ccc(OC)cc45)C2
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Biochem./physiol. Wirkung
CNS stimulant and hallucinogen; anti-convulsant.
Ibogaine is a central nervous system stimulant and hallucinogen that has been reported to be a σ2 agonist, a noncompetitive NMDA receptor antagonist at the phencyclidine site and an enhancer of purinergic muscle contractions. It is also a competitive inhibitor of serotonin and dopamine transport. It is an anti-convulsant and has anti-addictive properties against cocaine and heroin.
Angaben zur Herstellung
Aus dem afrikanischen Strauch Tabernanthe iboga isoliertes Alkaloid.
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M K Mundey et al.
British journal of pharmacology, 129(8), 1561-1568 (2000-04-26)
Ibogaine and 18-methoxycoronaridine are naturally occurring alkaloids reported to possess antiaddictive properties in several models of drug dependence. We have examined their effect at mu-opioid receptors regulating neurogenic contractions of several smooth muscle preparations and also against spontaneous contractions of
Y Itzhak et al.
Annals of the New York Academy of Sciences, 844, 245-251 (1998-07-21)
Although the alkaloid ibogaine is a potent hallucinogenic agent some indications suggest that it may be useful for the treatment of opioid and cocaine addiction. The neurochemical mechanism(s) underlying ibogaine effects remain unclear. In the present study we investigated the
S D Glick et al.
Annals of the New York Academy of Sciences, 909, 88-103 (2000-07-27)
Ibogaine, one of several alkaloids found in the root bark of the African shrub Tabernanthe iboga, has been claimed to be effective in treating multiple forms of drug abuse. Problems associated with side effects of ibogaine have spawned a search
K K Szumlinski et al.
Pharmacology, biochemistry, and behavior, 63(3), 457-464 (1999-07-27)
Pretreatment (19 h) with the putative antiaddictive agent, ibogaine, has been shown previously to potentiate cocaine-induced locomotion in rats. The present study demonstrates that the magnitude of this effect of ibogaine is dependent on the previous cocaine history of the
G B Wells et al.
Brain research bulletin, 48(6), 641-647 (1999-07-01)
Ibogaine has been shown to affect biogenic amine levels in selected brain regions. Because of the involvement of these neurotransmitters in drug addiction, the effects of ibogaine on biogenic amine transport may contribute to the potential anti-addictive properties of ibogaine
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