GW22561

Anti-SNX2 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• MDL-Nummer: MFCD02264101
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: chicken
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Speziesreaktivität: mouse, human, rat
• Methode(n): western blot: suitable
• NCBI-Hinterlegungsnummer: NP_003091.1
• UniProt-Hinterlegungsnummer: O60749
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... SNX2(6643)

Beschreibung

Allgemeine Beschreibung

SNX2 (sorting nexin 2) is a member of cytoplasmic and membrane proteins called SNXs. This protein is expressed in thyroid in the columnar and active follicular cells. It contains the PX (phox homology) domain, found in all SNX members, which binds to phosphatidylinositol 3-phosphate (PI3P). It also contains a BAR domain adjacent to its PX domain, towards the C-terminal. It is thought to form a dimer with other SNX member proteins, which in turn make a part of the heteropentameric complex called retromer. SNX2 also contains a coiled-coil domain in its C-terminal. It is a homologue of vacuolar protein-sorting (Vps)5p found in yeast. It has a molecular weight of ~68kDa.

Immunogen

Immunogen Sequence: GI # 4507141, sequence 1-519

Recombinant sorting nexin 2

Anwendung

Anti-SNX2 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem./physiol. Wirkung

Sorting nexin-2 (SNX2) acts as a novel marker for active thyrocytes and reflects the endosomal trafficking activity in these cells. It forms a component of the mammalian retromer complex that functions in the retrieval of the cation-independent mannose 6-phosphate receptor from endosomes to the trans-Golgi network. It is involved, though not necessary, in the lysosomal sorting of EGFR (epidermal growth factor receptor), which is internalized. Mouse embryos with inactivated SNX2 gene die mid-gestation. This study suggests that SNX2 is essential during developmental processes.

Physikalische Form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)