GW22346

Anti-BCAS2 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: chicken
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Speziesreaktivität: mouse, rat, human
• Hersteller/Markenname: Genway 15-288-22346
• Methode(n): western blot: suitable
• NCBI-Hinterlegungsnummer: NP_005863.1
• UniProt-Hinterlegungsnummer: O75934
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... BCAS2(10286)

Beschreibung

Immunogen

Immunogen Sequence: GI # 5031653, sequence 1-225

Recombinant breast carcinoma amplified sequence 2

Anwendung

Anti-BCAS2 antibody produced in chicken is suitable western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem./physiol. Wirkung

Pre-mRNA-splicing factor SPF27 is a protein encoded by the BCAS2 gene in humans and is mapped to chromosome 1p13.3-21 region. It codes for a nuclear protein. BCAS2 is a novel gene up-regulated by amplification in human breast cancer cell lines. It acts as a transcriptional coactivator of estrogen receptor. It directly interacts with p⁵³ to reduce p⁵³ transcriptional activity and consistently decreases p⁵³ protein in the absence of DNA damage. BCAS2 is a small nuclear protein (26kDa) and a novel negative regulator of p⁵³. It is a potential molecular target for cancer therapy.

Physikalische Form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)