GW20088F

Anti-HDL antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• MDL-Nummer: MFCD00162396
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: chicken
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Speziesreaktivität: human
• Hersteller/Markenname: Genway 15-288-20088F
• Methode(n): western blot: suitable
• UniProt-Hinterlegungsnummer: P28845
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... HSD11B1(3290)

Beschreibung

Immunogen

HDL human native protein.

Anwendung

Anti-HDL antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem./physiol. Wirkung

11β-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in metabolic tissues that include liver, adipose tissue and the central nervous system. It may contribute to the loss of muscle strength with age and is a key component of sarcopenia. Inhibition of HDL gene may have some therapeutic potential in sarcopenia. HDL gene variation may affect the physiological cortisol levels and the severity of age-related osteoporosis. It is involved in regenerating active glucocorticoids, that are selectively elevated in adipose tissue in human obesity and metabolic syndrome, both associated with chronic low-grade inflammation. HDL acts as an oxidoreductase to yield active glucocorticoids, cortisol or corticosterone. It is expressed in normal human epidermal keratinocytes (NHEKs) and negatively regulates proliferation of NHEKs.

Physikalische Form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)