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GW20021F

Sigma-Aldrich

Anti-Fibronectin Antibody

chicken polyclonal

Synonym(e):

Anti-Cold-insoluble globulin, Anti-FN

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About This Item

MDL-Nummer:
MFCD00162291
UNSPSC-Code:
12352203
NACRES:
NA.41

product name

Anti-Fibronectin antibody produced in chicken, affinity isolated antibody, buffered aqueous solution

Biologische Quelle

chicken

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Speziesreaktivität

human, mouse, rat

Hersteller/Markenname

Genway 15-288-20021F

Konzentration

1.0-1.2 mg/mL

Methode(n)

indirect ELISA: suitable
western blot: suitable

NCBI-Hinterlegungsnummer

CAA26536.1

UniProt-Hinterlegungsnummer

P02751

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... FN1(2335)

Allgemeine Beschreibung

The gene FN1 (Fibronectin) is mapped to human chromosome 2q34. It is present as a soluble dimeric form in plasma. At the cell surface and in the extracellular matrix, it is present as a dimeric or multimeric form.

Immunogen

Fibronectin native protein.
Immunogen Sequence: GI # 31397, sequence 1-2328

Anwendung

Anti-Fibronectin antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200. It is also suitable for indirect ELISA.

Biochem./physiol. Wirkung

Fibronectin (FN1) is a glycoprotein that is involved in cell adhesion and migration processes, such as embryogenesis, wound healing, blood coagulation, host defense, and metastasis. It binds to cell surfaces and compounds, such as collagen, fibrin, heparin, fibulin, integrins, cell adhesive mac-2 binding protein (M2BP), cartilage oligomeric matrix protein (COMP), DNA, and actin. Fibronectin interaction with FLRG (Follistatin-related gene protein) and follistatin is important for human hematopoietic cell adhesiveness. It is associated with glomerulopathy with fibronectin deposits, an autosomal dominant disease. Polymorphism in gene is linked with increased risk of knee osteoarthritis. Human pathogens, Staphylococcus aureus and Streptococcus pyogenes, target fibronectin for adhesion to and invasion of host cells. Pigment epithelium-derived factor (PEDF) down-regulates fibronectin to suppress breast cancer metastasis.

Physikalische Form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

R Carlsson et al.
Proceedings of the National Academy of Sciences of the United States of America, 78(4), 2403-2406 (1981-04-01)
Laminin, a basement membrane glycoprotein isolated from cultures of mouse endodermal cells and rat yolk sac carcinoma cells, promoted the attachment of liver cells obtained from regenerating mouse liver. Cells from normal mouse liver attached readily to dishes coated with
Mohamed Reda Fazazi et al.
Nature communications, 15(1), 5404-5404 (2024-06-27)
B cells and T cells collaborate in multiple sclerosis (MS) pathogenesis. IgH[MOG] mice possess a B cell repertoire skewed to recognize myelin oligodendrocyte glycoprotein (MOG). Here, we show that upon immunization with the T cell-obligate autoantigen, MOG[35-55], IgH[MOG] mice develop
C Ffrench-Constant et al.
The Journal of cell biology, 109(2), 903-914 (1989-08-01)
The adhesive extracellular matrix glycoprotein fibronectin (FN) is thought to play an important role in the cell migration associated with wound healing. Immunolocalization studies show abundant FN in healing wounds; however, these studies cannot define the cellular site(s) of FN
E Engvall et al.
International journal of cancer, 20(1), 1-5 (1977-07-15)
Fibronectin, a plasma protein immunologically identical with a major surface protein of normal fibroblasts, was found to bind to collagen and gelatin. A solid phase enzyme immunoassay was used for the binding tests. Collagen, gelatin or various control proteins were
Ulrich Schwarz-Linek et al.
Nature, 423(6936), 177-181 (2003-05-09)
Staphylococcus aureus and Streptococcus pyogenes, two important human pathogens, target host fibronectin (Fn) in their adhesion to and invasion of host cells. Fibronectin-binding proteins (FnBPs), anchored in the bacterial cell wall, have multiple Fn-binding repeats in an unfolded region of
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