G8919
Anti-Growth Hormone Receptor antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonym(e):
Anti-GHR
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About This Item
Empfohlene Produkte
Biologische Quelle
goat
Qualitätsniveau
Konjugat
unconjugated
Antikörperform
affinity isolated antibody
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Form
lyophilized powder
Speziesreaktivität
mouse
Methode(n)
immunohistochemistry: 5-15 μg/mL using cells and tissues
western blot: 0.1-0.2 μg/mL
UniProt-Hinterlegungsnummer
Lagertemp.
−20°C
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
mouse ... Ghr(14600)
Allgemeine Beschreibung
By immunoblotting, this antibody shows ~50% cross-reactivity with recombinant rat GHR and 20% cross-reactivty with recombinant human GHR.
Growth Hormone Receptor encodes a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of intra- and intercellular signal transduction pathways.
Immunogen
purified, NSO-derived, recombinant mouse growth hormone receptor extracellular domain.
Anwendung
Anti-Growth Hormone Receptor antibody produced in goat was used to study the protein and protein phosphorylation levels in rat primary hippocampal cultures using Li-cor Odyssey fluorescence technology.
Biochem./physiol. Wirkung
Growth hormone (GH) is secreted by the anterior pituitary and functions by binding specific growth hormone receptor (GHR). GH stimulates the secretion of insulin-like growth factor-1 that mediates some of its growth promoting actions. The activity of GH/GHR is important for normal physiology and aging processes.
Physikalische Form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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Juan Ding et al.
Proteomics, 13(3-4), 674-685 (2012-09-29)
Growth hormone (GH) is a protein secreted by the anterior pituitary and circulates throughout the body to exert important actions on growth and metabolism. GH stimulates the secretion of insulin-like growth factor-I (IGF-I) that mediates some of the growth promoting
Zhongbo Liu et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30(2), 635-652 (2015-10-21)
Bone minerals are acquired during growth and are key determinants of adult skeletal health. During puberty, the serum levels of growth hormone (GH) and its downstream effector IGF-1 increase and play critical roles in bone acquisition. The goal of the
George A Garinis et al.
Nature cell biology, 11(5), 604-615 (2009-04-14)
The accumulation of stochastic DNA damage throughout an organism's lifespan is thought to contribute to ageing. Conversely, ageing seems to be phenotypically reproducible and regulated through genetic pathways such as the insulin-like growth factor-1 (IGF-1) and growth hormone (GH) receptors
Andrzej Bartke et al.
Endokrynologia Polska, 64(1), 46-52 (2013-03-02)
Studies in mutant, gene knock-out and transgenic mice have demonstrated that growth hormone (GH) signalling has a major impact on ageing and longevity. Growth hormone-resistant and GH-deficient animals live much longer than their normal siblings, while transgenic mice overexpressing GH
F J Steyn et al.
Endocrinology, 154(12), 4695-4706 (2013-10-11)
GH deficiency is thought to be involved in the pathogenesis of amyotrophic lateral sclerosis (ALS). However, therapy with GH and/or IGF-I has not shown benefit. To gain a better understanding of the role of GH secretion in ALS pathogenesis, we
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