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G0774

Sigma-Aldrich

Glycerokinase from Bacillus stearothermophilus

buffered aqueous solution, ≥75 units/mg protein (biuret)

Synonym(e):

ATP:glycerol 3-phosphotransferase, Glycerin-Kinase

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About This Item

CAS-Nummer:
9030-66-4
EC-Nummer:
2.7.1.30 (BRENDA, IUBMB)
EG-Nummer:
232-862-0
MDL-Nummer:
MFCD00131205
UNSPSC-Code:
12352204
eCl@ss:
32160410
NACRES:
NA.54

Biologische Quelle

Bacillus sp. (Bacillus steaarothermophilus)

Assay

≥5.0 mg protein/mL (biuret)

Form

buffered aqueous solution

Spezifische Aktivität

≥75 units/mg protein (biuret)

Lagerbedingungen

dry at room temperature

Farbe

beige

Anwendung(en)

life science and biopharma

Lagertemp.

2-8°C

Angaben zum Gen

Bacillus sp. ... glpK(89613566)

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Allgemeine Beschreibung

Research area: Cell Signaling

Glycerol kinase is encoded by the GK gene on chromosome Xp21.2. Glycerol kinase is predominantly active in the liver.

Anwendung

Glycerokinase from Bacillus stearothermophilus has been used in steady-state kinetics studies.

Biochem./physiol. Wirkung

Glycerol kinase catalyzes tge MgATP-dependent phosphorylation of glycerol to produce sn-glycerol-3-phosphate and is the rate limiting enzyme in the utilization of glycerol. It is also subject to feedback regulation by fructose-1,6-bisphosphate.Oxidized glycerol-3-phosphate results in dihydroxyacetone phosphate which enters either glycolysis or gluconeogenesis. Elevated glycerol is observed in glycerol kinase deficiency leading to pseudohypertriglyceridemia.

Einheitendefinition

One unit will convert 1.0 μmole of glycerol and ATP to L-α-glycerophosphate and ADP per min at pH 9.8 at 25 °C in a coupled system with PK/LDH.

Physikalische Form

Stabilized solution in Tris buffer, pH 7.3

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H334

Gefahreneinstufungen

Resp. Sens. 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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Carol J Hartley et al.
PloS one, 12(11), e0184183-e0184183 (2017-11-08)
Carbon-carbon bond formation is one of the most challenging reactions in synthetic organic chemistry, and aldol reactions catalysed by dihydroxyacetone phosphate-dependent aldolases provide a powerful biocatalytic tool for combining C-C bond formation with the generation of two new stereo-centres, with
N Zwaig et al.
Science (New York, N.Y.), 153(3737), 755-757 (1966-08-12)
Fructose-1 ,6-diphosphate is a feedback inhibitor of the catabolic enzyme, glycerol kinase, in Escherichia coli. A mutant was isolated which produced a desensitized enzyme. Glucose was no longer as effective in preventing the utilization of exogenous glycerol by cells which
Purification and properties of glycerol kinase from Escherichia coli.
S I Hayashi et al.
The Journal of biological chemistry, 242(5), 1030-1035 (1967-03-10)
Anita Pillai et al.
Diabetes technology & therapeutics, 13(9), 945-949 (2011-07-01)
Obstructive sleep apnea (OSA), a highly prevalent condition, is independently associated with increased risks of developing type 2 diabetes mellitus (T2D) and metabolic syndrome. It is unclear, however, if the severity of OSA has any impact on glycemic control among
Anesthesia for a child suffering from a deletion in the Xp21 loci resulting in Duchenne disease, glycerol kinase deficiency, and congenital adrenal hypoplasia.
Luc J Van Obbergh et al.
Paediatric anaesthesia, 21(10), 1085-1087 (2011-10-11)
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