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F5804

Sigma-Aldrich

Anti-FBG3 (FBXO44) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(e):

Anti-F Box 3

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About This Item

MDL-Nummer:
MFCD08705455
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

200

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Mol-Gew.

antigen ~30 kDa by calculation

Speziesreaktivität

human

Methode(n)

western blot: 1:500-1:1,000

UniProt-Hinterlegungsnummer

Q9H4M3

Versandbedingung

dry ice

Lagertemp.

−20°C

Angaben zum Gen

human ... FBXO44(93611)
mouse ... Fbxo44(230903)
rat ... Fbxo44(500587)

Immunogen

peptide corresponding to the human FBG3 protein (amino acids 103-119). This sequence has 94% homology with mouse and rat.

Anwendung

Anti-FBG3 (FBXO44) antibody is suitable for western blot: 1:500-1:1,000.

Biochem./physiol. Wirkung

F-box protein, is the critical component of conserved ubiquitin–protein ligase complex SCF (Skp1/Cdc53-Cullin1/F-box) and acts as a substrate recognition component of the ubiquitin ligase complex SCF (Skp-Cullin-F-box). It is expressed in human tissues including kidney, liver, brain and muscle tissues. It is associated with various critical biological processes such as in regulating the cell cycle, immune response, signaling cascades and developmental programs. The proteins have a bipartite structure and the core complex, whereas divergent protein-protein interaction motifs selectively bind their cognate substrates.

Physikalische Form

Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

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Lagerklassenschlüssel

10 - Combustible liquids

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Gennady P Ilyin et al.
Gene, 296(1-2), 11-20 (2002-10-18)
F-box proteins, a critical component of the evolutionary conserved ubiquitin-protein ligase complex SCF (Skp1/Cdc53-Cullin1/F-box), recruit substrates for ubiquitination and consequent degradation through their specific protein-protein interaction domains. Here, we report the identification of full-length cDNAs encoding three novel human F-box
K L Craig et al.
Progress in biophysics and molecular biology, 72(3), 299-328 (1999-12-03)
The ubiquitin system of intracellular protein degradation controls the abundance of many critical regulatory proteins. Specificity in the ubiquitin system is determined largely at the level of substrate recognition, a step that is mediated by E3 ubiquitin ligases. Analysis of
Margaret S Ho et al.
Journal of biomedical science, 13(2), 181-191 (2006-02-08)
The eukaryotic protein degradation pathway involves the ubiquitin (Ub) modification of substrates targeted for degradation by the 26S proteasome. The addition of Ub, a process called ubiquitination, is mediated by enzymes including the E3 Ub ligases which transfer the Ub
Laura Pontano Vaites et al.
Molecular and cellular biology, 31(22), 4513-4523 (2011-09-14)
Skp1-Cul1-F-box (SCF) E3 ubiquitin ligase complexes modulate the accumulation of key cell cycle regulatory proteins. Following the G(1)/S transition, SCF(Fbx4) targets cyclin D1 for proteasomal degradation, a critical event necessary for DNA replication fidelity. Deregulated cyclin D1 drives tumorigenesis, and

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