F133

Norfluoxetin -hydrochlorid

≥97%, solid

• Synonym(e): (±)-γ-(4-Trifluoromethylphenoxy)-benzolpropanamin -hydrochlorid
• Empirische Formel (Hill-System): C₁₆H₁₆F₃NO · HCl
• CAS-Nummer: 57226-68-3
• Molekulargewicht: 331.76
• MDL-Nummer: MFCD01321043
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24894760
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97%
• Form: solid
• Farbe: yellow
• Löslichkeit: H₂O: >4 mg/mL; DMSO: >5 mg/mL
• SMILES String: Cl[H].NCCC(Oc1ccc(cc1)C(F)(F)F)c2ccccc2
• InChI: 1S/C16H16F3NO.ClH/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12;/h1-9,15H,10-11,20H2;1H
• InChIKey: GMTWWEPBGGXBTO-UHFFFAOYSA-N

Beschreibung

Anwendung

Norfluoxetine hydrochloride has been used to examine if psychoactive pharmaceuticals in drinking water at environmental concentrations could induce neuronal gene expression. It has also been used to examine whether at environmental concentrations it can alter in vitro expression of autism spectrum disorders (ASD)-associated synaptic proteins in human neurons.

Biochem./physiol. Wirkung

Fluoxetine metabolite; more potent inhibitor of serotonin uptake than fluoxetine with a half-life in vivo of 5-7 days.

Norfluoxetine is an active metabolite of fluoxetine. It disturbs the production of estrogen in a co-culture model of the feto-placental unit.

Vorsicht

Hygroscopic, photosensitive

Rechtliche Hinweise

Verkauf lizenziert von Eli Lilly and Company.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)