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E6886

Sigma-Aldrich

5-Ethyluracil

Synonym(e):

2,4-Dihydroxy-5-ethylpyrimidine, Homothymine

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About This Item

Empirische Formel (Hill-System):
C6H8N2O2
CAS-Nummer:
4212-49-1
Molekulargewicht:
140.14
MDL-Nummer:
MFCD00079187
UNSPSC-Code:
41106305
PubChem Substanz-ID:
24894638

mp (Schmelzpunkt)

>300 °C (lit.)

SMILES String

CCC1=CNC(=O)NC1=O

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Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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V Thielking et al.
Biological chemistry, 378(5), 407-415 (1997-05-01)
Steady-state kinetics of the N6-adenine Dam methyltransferase have been measured using as substrates non-self-complementary tetradecanucleotide duplexes that contain the GATC target sequence. Modifications in the GATC target sequence of one or both of the strands included substitution of guanine by
Montserrat Terrazas et al.
Molecular diversity, 15(3), 677-686 (2010-11-17)
Oligoribonucleotides carrying 5-ethyluridine units were prepared using solid-phase phosphoramidite chemistry. The introduction of the tert-butyldimethylsilyl group at the 2'-OH position proceeded in good yield and very high 2'-regioselectivity. RNA duplexes carrying 5-ethyluridine either at the sense or the guide strands
J L Fischel et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 1(9), 991-996 (1995-09-01)
Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme of 5-fluorouracil (FU) catabolism. Ethynyluracil (776C) is a very potent, mechanism-based irreversible DPD inhibitor that improves the antitumor efficacy and the therapeutic index of FU in laboratory animals. We tested the cytotoxic effects
S Marzabal et al.
Nucleic acids research, 23(18), 3648-3655 (1995-09-25)
We have measured steady-state kinetics of the N6-adenine methyltransferase Dam Mtase using as substrates non-selfcomplementary tetradecamer duplexs (d[GCCGGATCTAGACG]-d[CGTCTAGATCC-GGC]) containing the hemimethylated GATC target sequence in one or the other strand and modifications in the GATC target sequence of the complementary
T Hayakawa et al.
Nucleic acids research, 16(11), 4761-4776 (1988-06-10)
Decadeoxyribonucleotides containing uracil, 5-bromouracil, 5-cyanouracil and 5-ethyluracil in recognition sequences of restriction endonucleases Bgl II, Sau 3AI, Mbo I were synthesized. Decanucleotides containing 5-bromouracil in place of thymine had essentially the same susceptibility to all the restriction endonucleases. Uracil-containing decanucleotides
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