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E3789
Amphotericin B – Low Endotoxin
Less than 5 EU/mg, suitable for cell culture
Synonym(e):
Amphotericin B – Low Endotoxin
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| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
100 mg | Voraussichtlich HEUTE zu versendenvonSchnelldorf | 91,40 € |
500 mg | Warenkorb auf Verfügbarkeit prüfen | 376,00 € 319,60 € |
1 g | Voraussichtlich HEUTE zu versendenvonSchnelldorf | 625,00 € |
Über diesen Artikel
NACRES:
NA.76
UNSPSC Code:
12352207
Technischer Dienst
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Unterstützung erhaltenbiological source
Streptomyces sp. (Microbial)
form
powder
mol wt
924.08
technique(s)
cell culture | mammalian: suitable
storage temp.
2-8°C
General description
Amphotericin B is a polyene antifungal antibiotic from Streptomyces sp. It has a high affinity for sterols,primarily ergosterols, of fungal and bacterial cell membranes.After binding to sterols, it forms channels in the membranes, causing small molecules to leak out.Amphotericin B is effective against fungi and yeast.The name of the drug is derived from the amphoteric behavior of the drug, due to the carboxyl group on the main ring and a primary amino group on the mycosamine ring.
Amphotericin B induces K+ leakage, which is separate from its lethal action, as was demonstrated in human erythrocytes and is due to the inhibitory effect on the Na+/K+ pump.At sub-lethal concentrations, this drug stimulates either the activity of some membrane enzymes or cellular metabolism,in particular stimulation of some cells of the immune system.
Amphotericin B induces K+ leakage, which is separate from its lethal action, as was demonstrated in human erythrocytes and is due to the inhibitory effect on the Na+/K+ pump.At sub-lethal concentrations, this drug stimulates either the activity of some membrane enzymes or cellular metabolism,in particular stimulation of some cells of the immune system.
Preparation Note
Amphotericin B remains active for 3 days in culture at 37°C. For long term, storage at 2−8°C, protected from air and light, is recommended. Under these conditions the products remain active for 5 years.
If reconstituted at 25 mg/10 mL of sterile water, there is no need to filter sterilize. This will yield a slightly hazy yellow solution.
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Dieser Artikel | |||
|---|---|---|---|
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) - |
| form powder | form liquid | form solid | form powder |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
| biological source Streptomyces sp. (Microbial) | biological source - | biological source Streptomyces sp. | biological source Streptomyces sp. |
| mol wt 924.08 | mol wt - | mol wt - | mol wt - |
signalword
Danger
hcodes
Hazard Classifications
STOT RE 1
Lagerklasse
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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