E1151

Anti-ERAB antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(e): Anti-Endoplasmic Reticulum-Associated Amyloid β-Peptide-Binding Protein
• MDL-Nummer: MFCD02096320
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen 27 kDa
• Speziesreaktivität: human
• Verpackung: antibody small pack of 25 μg
• Methode(n): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1-2 μg/mL using human cerebellum tissue; western blot: 1-3 μg/mL using human SK-N-SH cells
• UniProt-Hinterlegungsnummer: Q99714
• Versandbedingung: wet ice
• Lagertemp.: 2-8°C
• Angaben zum Gen: human ... HSD17B10(3028)

Beschreibung

Allgemeine Beschreibung

The gene HSD17B10 (hydroxysteroid (17-β) dehydrogenase 10) encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily.

Spezifität

By immunoblotting, the antibody detects native human ERAB. It does not react with mouse or rat.

Immunogen

synthetic peptide corresponding to amino acids 100-116 of human ERAB protein.

Anwendung

Anti-ERAB antibody produced in rabbit is suitable for immunohistochemistry at a working concentration of 1-2μg/mL using human cerebellum tissue with DAB detection and for immunoblotting at 1-3μg/mL using human neuroblastoma SK-N-SH cells with chemiluminescence detection.

Biochem./physiol. Wirkung

The gene product is a subunit of mitochondrial ribonuclease P and plays a pivotal role in in mitochondrial tRNA maturation. It catalyzes the oxidation of a wide variety of fatty acids and steroids. The gene is linked to the neuronal dysfunction associated with Alzheimer disease (AD).

Physikalische Form

Solution in 0.05 M sodium phosphate buffer, pH 7.5, containing 0.2% gelatin and 0.1% sodium azide

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves