E0514

E-64c

Calpain Inhibitor

• Synonym(e): (2S,3S)-trans-Epoxysuccinyl-L-leucylamido-3-methyl-butan
• Empirische Formel (Hill-System): C₁₅H₂₆N₂O₅
• CAS-Nummer: 76684-89-4
• Molekulargewicht: 314.38
• MDL-Nummer: MFCD00132882
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 24894369

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Assay: ≥98% (HPLC)
• Form: powder
• Löslichkeit: ethanol: 20 mg/mL, clear, colorless
• Lagertemp.: −20°C
• SMILES String: CC(C)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H]1O[C@@H]1C(O)=O
• InChI: 1S/C15H26N2O5/c1-8(2)5-6-16-13(18)10(7-9(3)4)17-14(19)11-12(22-11)15(20)21/h8-12H,5-7H2,1-4H3,(H,16,18)(H,17,19)(H,20,21)/t10-,11-,12-/m0/s1
• InChIKey: SCMSYZJDIQPSDI-SRVKXCTJSA-N
• Angaben zum Gen: human ... CAPN1(823)

Beschreibung

Biochem./physiol. Wirkung

Cysteine protease inhibitor; membrane-impermeable calpain inhibitor.

Cysteine protease inhibitor; membrane-impermeable calpain inhibitor. Significantly reduces calpain-mediated depletion of microtubule-associated protein (MAP2) in an animal model of an ischemic brain.

Verlinkung

Synthetic analog of E-64

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)