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Wichtige Dokumente
D9549
[Phe4]-Dermorphin fragment 1-4 amide
≥97% (HPLC)
Synonym(e):
TAPP, Tyr-D-Ala-Phe-Phe-NH2
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About This Item
Empirische Formel (Hill-System):
C30H35N5O5
CAS-Nummer:
Molekulargewicht:
545.63
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
Assay
≥97% (HPLC)
Lagertemp.
−20°C
SMILES String
CC(NC(=O)C(N)Cc1ccc(O)cc1)C(=O)NC(Cc2ccccc2)C(=O)NC(Cc3ccccc3)C(N)=O
Angaben zum Gen
human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988)
Biochem./physiol. Wirkung
Selective μ opiate receptor agonist; lipophilic peptide that appears to cross the blood-brain barrier.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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J Gutkowska et al.
British journal of pharmacology, 119(2), 239-244 (1996-09-01)
1. The effect of i.v. administration of TAPP, a highly selective and exclusively peripherally-acting mu-opioid receptor agonist, on urine output, urinary sodium, potassium and cyclic GMP, and on plasma immunoreactive atrial natriuretic factor (IR-ANF) levels was studied in conscious normally
M Spetea et al.
Peptides, 19(6), 1091-1098 (1998-08-13)
Opioid receptor binding properties of [3H]Tyr-D-Ala-Phe-Phe-NH2 (TAPP) were characterized in rat brain and Chinese hamster ovary (CHO) cells expressing the rat mu-receptor. In rat brain, [3H]TAPP labeled a single class of opioid sites with a dissociation constant (Kd) of 0.31
P W Schiller et al.
Journal of medicinal chemistry, 32(3), 698-703 (1989-03-01)
According to the membrane compartment concept the receptor specificity of ligands is based not only on ligand-receptor complementarity but also on specific ligand-membrane interactions. Elaboration of this concept for opioid peptide-receptor interactions had led to the assumption that mu- and
Sana S Dastgheyb et al.
Clinical orthopaedics and related research, 473(9), 2865-2873 (2015-04-22)
Allograft bone is commonly used to augment bone stock. Unfortunately, allograft is prone to bacterial contamination and current antimicrobial therapies are inadequate. Photoactivated porphyrins combat bacterial growth by production of reactive oxygen species (ROS); however, to our knowledge, they have
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