D8668

2′-Desoxyadenosin Monohydrat

powder, BioReagent, suitable for cell culture

• Synonym(e): 9-(2-Deoxy-β-D-ribofuranosyl)-adenin, Adenindesoxyribosid
• Empirische Formel (Hill-System): C₁₀H₁₃N₅O₃ · H₂O
• CAS-Nummer: 16373-93-6
• Molekulargewicht: 269.26
• Beilstein: 91015
• EG-Nummer: 213-488-7
• MDL-Nummer: MFCD00005754
• UNSPSC-Code: 12352207
• PubChem Substanz-ID: 24894112
• NACRES: NA.75

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Produktlinie: BioReagent
• Assay: ≥99% (HPLC)
• Form: powder
• Methode(n): cell culture | mammalian: suitable
• Löslichkeit: H₂O: soluble 25 mg/mL, clear to slightly hazy, colorless to faintly yellow
• Lagertemp.: 2-8°C
• SMILES String: [H]O[H].Nc1ncnc2n(cnc12)[C@H]3C[C@H](O)[C@@H](CO)O3
• InChI: 1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1
• InChIKey: OLXZPDWKRNYJJZ-RRKCRQDMSA-N

Beschreibung

Anwendung

2′-Deoxyadenosine monohydrate has been used as a nucleotide precursor:

• To study the importance of homologous recombination at the interface between replication and mitosis
• To analyze deoxynucleoside-assisted transductions
• To study the effect of increased deoxycytidine on gemcitabine resistance in pancreatic cancer cells

2′-Deoxyadenosine monohydrate has been used for the preparation of deoxyribonucleoside stock solution for the anaerobic culture of Bacillus mojavensis strains including JF-2 and two Bacillus subtilis strains.

Biochem./physiol. Wirkung

Excess 2′-deoxyadenosine gets converted to adenosine triphosphate (dATP), which inhibits ribonucleotide reductase.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves